CORO1C coronin 1C [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO1Cprovided by HGNC
Official Full Name: coronin 1Cprovided by HGNC
Primary source: HGNC:HGNC:2254
See related: Ensembl:ENSG00000110880 MIM:605269; AllianceGenome:HGNC:2254
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HCRNN4
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]
Expression: Ubiquitous expression in endometrium (RPKM 30.8), lung (RPKM 27.0) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (108645109..108731518, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (108619700..108706142, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (109038885..109125294, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.
Title: Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.
CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells.
Title: CORO1C, a novel PAK4 binding protein, recruits phospho-PAK4 at serine 99 to the leading edge and promotes the migration of gastric cancer cells.
CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.
Title: CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.
Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.
Title: Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.
Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.
Title: Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.
Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
Title: Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis.
A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.
Title: A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.
Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis.
Title: Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis.
MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C.
Title: MiR-206 may suppress non-small lung cancer metastasis by targeting CORO1C.
miR-26 suppresses renal cell cancer via down-regulating coronin-3.
Title: miR-26 suppresses renal cell cancer via down-regulating coronin-3.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N68222 (e-PCR)
- UniSTS:12821

RH123095 (e-PCR)
- UniSTS:135475

D9S1794 (e-PCR)
- UniSTS:42807

SGC32397 (e-PCR)
- UniSTS:83267

SHGC-109998 (e-PCR)
- UniSTS:170151

WI-20941 (e-PCR)
- UniSTS:42174

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in corpus callosum development	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IDA Inferred from Direct Assay more info	PubMed
involved_in endosome fission	IDA Inferred from Direct Assay more info	PubMed
involved_in endosome membrane tubulation	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane fission	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neural crest cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of lamellipodium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of focal adhesion assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of substrate adhesion-dependent cell spreading	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in ventricular system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
part_of flotillin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in focal adhesion	HDA more info	PubMed
NOT colocalizes_with focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
colocalizes_with vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-1C

Names: coronin, actin binding protein, 1C; coronin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105237.2 → NP_001098707.1 coronin-1C isoform a

See identical proteins and their annotated locations for NP_001098707.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC007569, AM849478, BM677390

Consensus CDS

CCDS61236.1

UniProtKB/TrEMBL

B3KN06, Q53G58

Related

ENSP00000394496.2, ENST00000420959.6

Conserved Domains (5) summary

pfam05873
Location:471 → 527

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

pfam08953
Location:59 → 116

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:396 → 438

WD40_4; Type of WD40 repeat

sd00039
Location:89 → 131

7WD40; WD40 repeat [structural motif]

cl02567
Location:128 → 353

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001276471.2 → NP_001263400.1 coronin-1C isoform b

See identical proteins and their annotated locations for NP_001263400.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AC007569, AK096363, BM677390

Consensus CDS

CCDS9120.1

UniProtKB/Swiss-Prot

A7MAP0, A7MAP1, B3KU12, Q9NSK5, Q9ULV4

UniProtKB/TrEMBL

B3KN06, Q53G58

Related

ENSP00000438341.1, ENST00000541050.5

Conserved Domains (3) summary

sd00039
Location:36 → 78

7WD40; WD40 repeat [structural motif]

pfam05873
Location:418 → 474

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

cl25676
Location:8 → 402

WD40_4; Type of WD40 repeat
NM_014325.4 → NP_055140.1 coronin-1C isoform b

See identical proteins and their annotated locations for NP_055140.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) has an alternate first exon and initiates translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).

Source sequence(s)

AB030656, AC007569, BM677390

Consensus CDS

CCDS9120.1

UniProtKB/Swiss-Prot

A7MAP0, A7MAP1, B3KU12, Q9NSK5, Q9ULV4

UniProtKB/TrEMBL

B3KN06, Q53G58

Related

ENSP00000261401.3, ENST00000261401.8

Conserved Domains (3) summary

sd00039
Location:36 → 78

7WD40; WD40 repeat [structural motif]

pfam05873
Location:418 → 474

Mt_ATP-synt_D; ATP synthase D chain, mitochondrial (ATP5H)

cl25676
Location:8 → 402

WD40_4; Type of WD40 repeat