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    C4orf36 chromosome 4 open reading frame 36 [ Homo sapiens (human) ]

    Gene ID: 132989, updated on 10-Dec-2024

    Summary

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    Official Symbol
    C4orf36provided by HGNC
    Official Full Name
    chromosome 4 open reading frame 36provided by HGNC
    Primary source
    HGNC:HGNC:28386
    See related
    Ensembl:ENSG00000163633 AllianceGenome:HGNC:28386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Broad expression in testis (RPKM 1.7), skin (RPKM 1.1) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See C4orf36 in Genome Data Viewer
    Location:
    4q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (86876205..86936204, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (90205627..90265613, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (87797358..87857356, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 member 6 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:87778666-87779166 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15549 Neighboring gene ribosomal protein L6 pseudogene 13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:87813317-87813972 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:87836141-87836640 Neighboring gene Sharpr-MPRA regulatory region 3757 Neighboring gene ARPC1A pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:87856539-87857080 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:87857081-87857622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:87861204-87861704 Neighboring gene AFF1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21697 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:87879079-87879662 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:87880372-87881044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:87881045-87881716 Neighboring gene Sharpr-MPRA regulatory region 10323 Neighboring gene ALF transcription elongation factor 1 Neighboring gene Sharpr-MPRA regulatory region 12874 Neighboring gene Sharpr-MPRA regulatory region 10097/5096 Neighboring gene trans-2,3-enoyl-CoA reductase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21698 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21699 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21700 Neighboring gene Sharpr-MPRA regulatory region 119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15553 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:87934257-87934756 Neighboring gene NANOG hESC enhancer GRCh37_chr4:87955092-87955593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:87958100-87958600 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:87958601-87959101 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15554 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:87960255-87961006 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21702 Neighboring gene uncharacterized LOC105377320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21703 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21704

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A high-density genome-wide association screen of sporadic ALS in US veterans. Kwee LC, et al. PLoS One, 2012. PMID 22470424, Free PMC Article
    2. Genetic variants associated with disordered eating. Wade TD, et al. Int J Eat Disord, 2013 Sep. PMID 23568457, Free PMC Article
    3. Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity. Golkowski M, et al. Mol Cell, 2023 Mar 2. PMID 36736316, Free PMC Article
    4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
    5. Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy. Sun X, et al. Acta Pharm Sin B, 2022 Feb. PMID 35256949, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A high-density genome-wide association screen of sporadic ALS in US veterans.
    EBI GWAS Catalog
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Readthrough C4orf36

    Included gene: AFF1-AS1

    Homology

    Clone Names

    • MGC26744

    General protein information

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    Preferred Names
    uncharacterized protein C4orf36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369888.1 → NP_001356817.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      Consensus CDS
      CCDS3615.1
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9
      Related
      ENSP00000421141.1, ENST00000506308.5
      Conserved Domains (1) summary
      pfam15022
      Location:1 → 117
      DUF4522; Protein of unknown function (DUF4522)

    2. NM_001369889.1 → NP_001356818.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      Consensus CDS
      CCDS3615.1
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9
      Conserved Domains (1) summary
      pfam15022
      Location:1 → 117
      DUF4522; Protein of unknown function (DUF4522)

    3. NM_001414635.1 → NP_001401564.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    4. NM_001414636.1 → NP_001401565.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    5. NM_001414638.1 → NP_001401567.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    6. NM_001414639.1 → NP_001401568.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    7. NM_001414640.1 → NP_001401569.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    8. NM_001414641.1 → NP_001401570.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    9. NM_001414642.1 → NP_001401571.1  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9

    10. NM_144645.4 → NP_653246.2  uncharacterized protein C4orf36

      Status: VALIDATED

      Source sequence(s)
      AC093827
      Consensus CDS
      CCDS3615.1
      UniProtKB/Swiss-Prot
      Q96KX1
      UniProtKB/TrEMBL
      D6RGW9
      Related
      ENSP00000295898.3, ENST00000295898.8
      Conserved Domains (1) summary
      pfam15022
      Location:1 → 117
      DUF4522; Protein of unknown function (DUF4522)

    RNA

    1. NR_183013.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    2. NR_183014.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    3. NR_183015.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    4. NR_183016.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    5. NR_183017.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    6. NR_183018.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    7. NR_183019.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    8. NR_183020.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    9. NR_183021.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    10. NR_183022.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093827

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      86876205..86936204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      90205627..90265613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96KX1.2 GenPept UniProtKB/Swiss-Prot:Q96KX1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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