TGOLN2 trans-golgi network protein 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TGOLN2provided by HGNC
Official Full Name: trans-golgi network protein 2provided by HGNC
Primary source: HGNC:HGNC:15450
See related: Ensembl:ENSG00000152291 MIM:603062; AllianceGenome:HGNC:15450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TGN38; TGN46; TGN48; TGN51; TTGN2; hTGN46; hTGN48; hTGN51
Summary: This gene encodes a type I integral membrane protein that is localized to the trans-Golgi network, a major sorting station for secretory and membrane proteins. The encoded protein cycles between early endosomes and the trans-Golgi network, and may play a role in exocytic vesicle formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Annotation information: Annotation category: suggests misassembly
Expression: Ubiquitous expression in kidney (RPKM 63.9), thyroid (RPKM 61.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p11.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (85318027..85327989, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (85320018..85329980, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (85545150..85555112, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.
Title: Whole-exome sequencing reveals an association of rs112065068 in TGOLN2 gene with distant metastasis of non-small cell lung cancer.
Sorting of secretory proteins at the trans-Golgi network by human TGN46.
Title: Sorting of secretory proteins at the trans-Golgi network by human TGN46.
Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
Title: Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.
These results indicate that hepatitis E virus (HEV)forms membrane-associated particles in the cytoplasm, and that the released HEV particles with a lipid membrane retain the antigenicity of TGOLN2 on their surface.
Title: The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 2.
These analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders.
Title: Case-control association study of TGOLN2 in attempted suicide.
Observational study of gene-disease association. (HuGE Navigator)
Title: Case-control association study of TGOLN2 in attempted suicide.
These data have identified different itineraries for the retrograde transport of Shiga toxin and TGN38 and distinct retromer components that regulate the transport of these cargos.
Title: Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.
FXIII-A associated with podosomes & other structures adjacent to the plasma membrane, containing TGN46 & GM130 but not protein disulphide isomerase. FXIII-A was present in GM130-positive intracellular vesicles that could mediate its transport.
Title: Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag co-localizes with Rab9 and TGN38 in endosomes and trans-Golgi compartments	PubMed
Vpu	vpu	HIV-1 Vpu co-localizes with the trans-golgi network protein TGN46 in CD4+ T cells	PubMed
	vpu	Vpu interferes with tetherin trafficking to the cell-surface and causes a relocalization of the cellular tetherin with a TGN marker TGN46 in the TGN	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH12119 (e-PCR)
- UniSTS:777

RH93357 (e-PCR)
- UniSTS:89885

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-32579 (e-PCR)
- UniSTS:33391

D1S1425 (e-PCR)
- UniSTS:149621

STS-X94333 (e-PCR)
- UniSTS:24441

G19802 (e-PCR)
- UniSTS:17581

A001Y46 (e-PCR)
- UniSTS:17582

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in transport vesicle	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: trans-Golgi network integral membrane protein 2

Names: TGN38 homolog; trans-Golgi network glycoprotein 46; trans-Golgi network glycoprotein 48; trans-Golgi network glycoprotein 51; trans-Golgi network protein TGN51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_030379.2 RefSeqGene

Range

5308..15270

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001206840.2 → NP_001193769.1 trans-Golgi network integral membrane protein 2 isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a longer and distinct C-terminus, compared to isoform 1. This variant (2, A allele) differs at 1 nt position compared to variant 2, B allele.

Source sequence(s)

AA723637, AC093162, AF027516, AL710137, BC008461, BY798185

UniProtKB/TrEMBL

A0AAG2UW97

Conserved Domains (1) summary

PTZ00121
Location:55 → 330

PTZ00121; MAEBL; Provisional
NM_001206841.2 → NP_001193770.1 trans-Golgi network integral membrane protein 2 isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3, A allele) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to isoform 1. This variant (3, A allele) differs at 1 nt position compared to variant 3, B allele.

Source sequence(s)

AA723637, AC093162, AL710137, BC008461, BY798185

UniProtKB/TrEMBL

A0AAG2UWR8

Conserved Domains (1) summary

PTZ00121
Location:55 → 330

PTZ00121; MAEBL; Provisional
NM_001206844.2 → NP_001193773.1 trans-Golgi network integral membrane protein 2 isoform 4 precursor

See identical proteins and their annotated locations for NP_001193773.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice site and lacks an in-frame segment of the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AA723637, AC093162, BC008461, BX640868

Consensus CDS

CCDS56127.1

UniProtKB/Swiss-Prot

O43493

Related

ENSP00000381312.2, ENST00000398263.6

Conserved Domains (1) summary

PLN03237
Location:64 → 325

PLN03237; DNA topoisomerase 2; Provisional
NM_001368095.1 → NP_001355024.1 trans-Golgi network integral membrane protein 2 isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2, B allele) differs at 1 nt position, resulting in a premature stop codon, compared to variant 2, B allele. The encoded isoform (5) is shorter than isoform 2.

Source sequence(s)

AC093162

Consensus CDS

CCDS92789.1

UniProtKB/TrEMBL

A0AAG2UWR8

Related

ENSP00000387035.1, ENST00000409015.5
NM_001368096.1 → NP_001355025.1 trans-Golgi network integral membrane protein 2 isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3, B allele) differs at 1 nt position compared to variant 3, A allele. The encoded isoform (6) is the same length as isoform 3 but differs in sequence by 1 aa.

Source sequence(s)

AC093162

Consensus CDS

CCDS56126.1

UniProtKB/TrEMBL

A0A5F9UY30, A0AAG2UWR8

Related

ENSP00000386443.3, ENST00000409232.7
NM_006464.4 → NP_006455.2 trans-Golgi network integral membrane protein 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_006455.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.

Source sequence(s)

AA723637, AC093162, AL710137, BC008461

Consensus CDS

CCDS46351.1

UniProtKB/Swiss-Prot

B2R686, B8ZZ88, D6W5K3, F8W8W7, F8WBK2, J3KQ45, O15282, O43492, O43493, O43499, O43500, O43501, Q53G68, Q53GV2, Q6MZV1, Q6ZTM7, Q8N6T8, Q92760, Q96QL2

UniProtKB/TrEMBL

A0AAG2UY03

Related

ENSP00000366603.3, ENST00000377386.8

Conserved Domains (2) summary

pfam17818
Location:306 → 435

KCT2; Keratinocyte-associated gene product

NF000535
Location:40 → 274

MSCRAMM_SdrC; MSCRAMM family adhesin SdrC