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    ARL4A ARF like GTPase 4A [ Homo sapiens (human) ]

    Gene ID: 10124, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ARL4Aprovided by HGNC
    Official Full Name
    ARF like GTPase 4Aprovided by HGNC
    Primary source
    HGNC:HGNC:695
    See related
    Ensembl:ENSG00000122644 MIM:604786; AllianceGenome:HGNC:695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARL4
    Summary
    ADP-ribosylation factor-like 4A is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4A is similar to ARL4C and ARL4D and each has a nuclear localization signal and an unusually high guaninine nucleotide exchange rate. ARL4A is located in both the nuclear and extranuclear cell compartments. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 32.8), bone marrow (RPKM 17.5) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARL4A in Genome Data Viewer
    Location:
    7p21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (12686903..12690958)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (12817976..12822031)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (12726528..12730583)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375157 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:12714709-12715908 Neighboring gene apoptosis-inducing, TAF9-like domain 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17979 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:12726767-12727303 Neighboring gene small nucleolar RNA SNORA64/SNORA10 family Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12755219-12755886 Neighboring gene CRISPRi-validated cis-regulatory element chr7.1000 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:12768729-12769252 Neighboring gene NANOG hESC enhancer GRCh37_chr7:12860349-12860942 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:12879421-12879981 Neighboring gene RN7SK pseudogene 228

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ARL4A acts with GCC185 to modulate Golgi complex organization. Lin YC, et al. J Cell Sci, 2011 Dec 1. PMID 22159419
    2. Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation. Chi JH, et al. J Neurosurg, 2008 Feb. PMID 18240926
    3. Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. Lin MC, et al. Proc Natl Acad Sci U S A, 2022 Jul 26. PMID 35857868, Free PMC Article
    4. ADP-ribosylation factor-like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation. Chiang TS, et al. Mol Biol Cell, 2019 Jan 1. PMID 30427759, Free PMC Article
    5. ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Li CC, et al. Mol Biol Cell, 2007 Nov. PMID 17804820, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane.
      Title: Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane.
    2. Arl4A participates in Slit2/Robo1 signaling to modulate cell motility by regulating Cdc42 activity.
      Title: ADP-ribosylation factor-like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation.
    3. Deletion of the ARL4A-interacting region of GCC185 results in inability to maintain Golgi structure and modulate endosome-to-Golgi transport.
      Title: ARL4A acts with GCC185 to modulate Golgi complex organization.
    4. membrane targeting of ELMO via Arl4A promotes cytoskeletal reorganization including membrane ruffling and stress fiber disassembly via an ELMO-DOCK1800-Rac signaling pathway.
      Title: The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family.
    5. The loss of PTEN was shown to lead to increased levels of ARF4L protein but no change in transcript levels. The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma.
      Title: Increased expression of the glioma-associated antigen ARF4L after loss of the tumor suppressor PTEN. Laboratory investigation.
    6. Study shows that three related Arf-like GTPases Arl4a, Arl4c, and Arl4d, are able to recruit ARNO and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form.
      Title: The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ADP-ribosylation factor-like protein 4A
    Names
    ADP ribosylation factor like GTPase 4A
    ADP-ribosylation factor-like 4
    ADP-ribosylation factor-like 4A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037164.3 → NP_001032241.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_001032241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC011891, DB472672
      Consensus CDS
      CCDS5359.1
      UniProtKB/Swiss-Prot
      A4D119, P40617, P80418, Q49AF5
      Related
      ENSP00000349250.3, ENST00000356797.7
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    2. NM_001195396.2 → NP_001182325.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_001182325.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC011891, AU076407, BQ948724
      Consensus CDS
      CCDS5359.1
      UniProtKB/Swiss-Prot
      A4D119, P40617, P80418, Q49AF5
      Related
      ENSP00000385236.1, ENST00000404894.1
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    3. NM_005738.5 → NP_005729.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_005729.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AC011891, BQ948724
      Consensus CDS
      CCDS5359.1
      UniProtKB/Swiss-Prot
      A4D119, P40617, P80418, Q49AF5
      Related
      ENSP00000498350.1, ENST00000651779.1
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    4. NM_212460.4 → NP_997625.1  ADP-ribosylation factor-like protein 4A

      See identical proteins and their annotated locations for NP_997625.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC011891, DB451189
      Consensus CDS
      CCDS5359.1
      UniProtKB/Swiss-Prot
      A4D119, P40617, P80418, Q49AF5
      Related
      ENSP00000379899.2, ENST00000396664.2
      Conserved Domains (1) summary
      cd04152
      Location:18 → 200
      Arl4_Arl7; Arf-like 4 (Arl4) and 7 (Arl7) GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      12686903..12690958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      12817976..12822031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40617.2 GenPept UniProtKB/Swiss-Prot:P40617

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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