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    LYP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855453, updated on 11-Sep-2024

    Summary

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    Official Symbol
    LYP1
    Primary source
    SGD:S000005212
    Locus tag
    YNL268W
    See related
    AllianceGenome:SGD:S000005212; FungiDB:YNL268W; VEuPathDB:YNL268W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transport. Located in eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (138550..140385)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene arginine permease ALP1 Neighboring gene Bsc4p Neighboring gene 1-phosphatidylinositol 4-kinase Neighboring gene Ist1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane Lipid Requirements of the Lysine Transporter Lyp1 from Saccharomyces cerevisiae. van 't Klooster JS, et al. J Mol Biol, 2020 Jun 26. PMID 32413406, Free PMC Article
    2. Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae. Van't Klooster JS, et al. FEBS J, 2020 Oct. PMID 32096906, Free PMC Article
    3. Disentangling strictly self-serving mutations from win-win mutations in a mutualistic microbial community. Hart SFM, et al. Elife, 2019 Jun 4. PMID 31162049, Free PMC Article
    4. Asymmetry in inward- and outward-affinity constant of transport explain unidirectional lysine flux in Saccharomyces cerevisiae. Bianchi F, et al. Sci Rep, 2016 Aug 23. PMID 27550794, Free PMC Article
    5. Cloning and sequencing of the Saccharomyces cerevisiae gene LYP1 coding for a lysine-specific permease. Sychrova H, et al. Yeast, 1993 Jul. PMID 8368011

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae.
      Title: Extracellular loops matter - subcellular location and function of the lysine transporter Lyp1 from Saccharomyces cerevisiae.
    2. Membrane Lipid Requirements of the Lysine Transporter Lyp1 from Saccharomyces cerevisiae.
      Title: Membrane Lipid Requirements of the Lysine Transporter Lyp1 from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables basic amino acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in basic amino acid transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in eisosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    lysine permease
    NP_014131.1
    • Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      138550..140385
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183106.1 → NP_014131.1  TPA: lysine permease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014131.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0S6, P32487
      UniProtKB/TrEMBL
      B3LPA7, C7GP95, C8ZFX1
      Conserved Domains (1) summary
      TIGR00913
      Location:107 → 583
      2A0310; amino acid permease (yeast)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32487.2

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