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    DCLK2 doublecortin like kinase 2 [ Homo sapiens (human) ]

    Gene ID: 166614, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DCLK2provided by HGNC
    Official Full Name
    doublecortin like kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:19002
    See related
    Ensembl:ENSG00000170390 MIM:613166; AllianceGenome:HGNC:19002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CL2; DCK2; CLIK2; DCDC3; CLICK2; DCDC3B; DCAMKL2; CLICK-II
    Summary
    This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]
    Expression
    Biased expression in brain (RPKM 21.2), heart (RPKM 3.5) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCLK2 in Genome Data Viewer
    Location:
    4q31.23-q31.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (150078445..150257438)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (153399764..153581437)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (150999597..151178590)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 167 Neighboring gene RNA, U6 small nuclear 1230, pseudogene Neighboring gene Sharpr-MPRA regulatory region 14262 Neighboring gene VISTA enhancer hs1614 Neighboring gene RNA, U7 small nuclear 194 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:151209299-151209799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22014 Neighboring gene Sharpr-MPRA regulatory region 13510 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:151287541-151288222 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:151288223-151288903 Neighboring gene LPS responsive beige-like anchor protein Neighboring gene nei like DNA glycosylase 2 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5429 Neighboring gene uncharacterized LOC729558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene. Gorelik A, et al. Cell Mol Biol Lett, 2008. PMID 18618084, Free PMC Article
    2. Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma. Hu L, et al. Mol Cell, 2024 Feb 15. PMID 38211588,
    3. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. Edelman AM, et al. J Biol Chem, 2005 Mar 4. PMID 15611072
    4. Doublecortin-like kinase enhances dendritic remodelling and negatively regulates synapse maturation. Shin E, et al. Nat Commun, 2013. PMID 23385585, Free PMC Article
    5. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H, et al. Neuron, 2015 Nov 18. PMID 26526391, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
      Title: Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of autistic-like traits in a general population study of young adults.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC45428, DKFZp761I032

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein localization to nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyramidal neuron development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase DCLK2
    Names
    CaMK-like CREB regulatory kinase 2
    doublecortin and CaM kinase-like 2
    doublecortin domain-containing protein 3B
    doublecortin-like and CAM kinase-like 2
    NP_001035350.2
    NP_001035351.4
    NP_001397781.1
    XP_005262842.1
    XP_016863321.1
    XP_016863322.1
    XP_024309681.1
    XP_024309682.1
    XP_024309683.1
    XP_047305657.1
    XP_047305658.1
    XP_054205063.1
    XP_054205064.1
    XP_054205065.1
    XP_054205066.1
    XP_054205067.1
    XP_054205068.1
    XP_054205069.1
    XP_054205070.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040260.4 → NP_001035350.2  serine/threonine-protein kinase DCLK2 isoform a

      See identical proteins and their annotated locations for NP_001035350.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is known as exon-5-lacking transcript (PMIDs:15611072 and 18075264). It lacks an in-frame coding exon in the 5' region, as compared to variant 2. The resulting isoform (a) lacks an internal segment, as compared to isoform b.
      Source sequence(s)
      AB209181, AC093748, AI419589, DA122884
      Consensus CDS
      CCDS34076.1
      UniProtKB/Swiss-Prot
      C9J5Q9, Q59GC8, Q8N399, Q8N568
      UniProtKB/TrEMBL
      A0A0U1RR70
      Related
      ENSP00000296550.7, ENST00000296550.12
      Conserved Domains (3) summary
      smart00220
      Location:394 → 651
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:392 → 650
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    2. NM_001040261.5 → NP_001035351.4  serine/threonine-protein kinase DCLK2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is known as exon-5-containing transcript (PMIDs:15611072 and 18075264) and encodes the longer isoform (b).
      Source sequence(s)
      AC093748, AC105343, AL834498
      Consensus CDS
      CCDS47142.2
      UniProtKB/TrEMBL
      A0A0U1RR70
      Related
      ENSP00000303887.8, ENST00000302176.8
      Conserved Domains (3) summary
      smart00220
      Location:411 → 668
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:409 → 667
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    3. NM_001410852.1 → NP_001397781.1  serine/threonine-protein kinase DCLK2 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC093748, AC105343, AC118064
      Consensus CDS
      CCDS93647.1
      UniProtKB/TrEMBL
      A0A0U1RR70
      Related
      ENSP00000427235.1, ENST00000506325.5

    RNA

    1. NR_036614.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is known as exon-17/16-containing transcript (PMIDs:15611072 and 18075264). It has an alternate splice site in the middle region, resulting in 3 nts missing, and has an additional exon in the 3' region, which includes a translation stop codon and results in a nonsense-mediated mRNA decay candidate, as compared to variant 2. This transcript is developmentally regulated and most probably does not make a protein.
      Source sequence(s)
      AC093748, AC105343, BC032726
      Related
      ENST00000411937.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      150078445..150257438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007832.3 → XP_016863321.1  serine/threonine-protein kinase DCLK2 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RR70
      Related
      ENSP00000489372.1, ENST00000635524.1
      Conserved Domains (3) summary
      cd14184
      Location:409 → 667
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)
      cd17069
      Location:193 → 276
      DCX2; Dublecortin-like domain 2
      cd17141
      Location:70 → 154
      DCX1_DCLK2; Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2)

    2. XM_017007833.3 → XP_016863322.1  serine/threonine-protein kinase DCLK2 isoform X3

      UniProtKB/TrEMBL
      A0A0U1RR70

    3. XM_005262785.4 → XP_005262842.1  serine/threonine-protein kinase DCLK2 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RR70
      Conserved Domains (3) summary
      smart00220
      Location:410 → 667
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cd14184
      Location:408 → 666
      STKc_DCKL2; Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2)

    4. XM_024453913.2 → XP_024309681.1  serine/threonine-protein kinase DCLK2 isoform X4

      UniProtKB/TrEMBL
      A0A0U1RR70
      Conserved Domains (2) summary
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:392 → 561
      PKc_like; Protein Kinases, catalytic domain

    5. XM_024453914.2 → XP_024309682.1  serine/threonine-protein kinase DCLK2 isoform X5

      UniProtKB/TrEMBL
      A0A0U1RR70
      Conserved Domains (2) summary
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:391 → 591
      PKc_like; Protein Kinases, catalytic domain

    6. XM_024453915.2 → XP_024309683.1  serine/threonine-protein kinase DCLK2 isoform X6

      UniProtKB/TrEMBL
      A0A0U1RR70
      Conserved Domains (2) summary
      smart00537
      Location:67 → 157
      DCX; Domain in the Doublecortin (DCX) gene product
      cl21453
      Location:409 → 584
      PKc_like; Protein Kinases, catalytic domain

    7. XM_047449701.1 → XP_047305657.1  serine/threonine-protein kinase DCLK2 isoform X7

    8. XM_047449702.1 → XP_047305658.1  serine/threonine-protein kinase DCLK2 isoform X8

    RNA

    1. XR_007096380.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      153399764..153581437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349089.1 → XP_054205064.1  serine/threonine-protein kinase DCLK2 isoform X2

      UniProtKB/TrEMBL
      A0A0U1RR70

    2. XM_054349090.1 → XP_054205065.1  serine/threonine-protein kinase DCLK2 isoform X3

      UniProtKB/TrEMBL
      A0A0U1RR70

    3. XM_054349088.1 → XP_054205063.1  serine/threonine-protein kinase DCLK2 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RR70

    4. XM_054349091.1 → XP_054205066.1  serine/threonine-protein kinase DCLK2 isoform X4

      UniProtKB/TrEMBL
      A0A0U1RR70

    5. XM_054349092.1 → XP_054205067.1  serine/threonine-protein kinase DCLK2 isoform X5

      UniProtKB/TrEMBL
      A0A0U1RR70

    6. XM_054349093.1 → XP_054205068.1  serine/threonine-protein kinase DCLK2 isoform X6

      UniProtKB/TrEMBL
      A0A0U1RR70

    7. XM_054349094.1 → XP_054205069.1  serine/threonine-protein kinase DCLK2 isoform X7

    8. XM_054349095.1 → XP_054205070.1  serine/threonine-protein kinase DCLK2 isoform X8

    RNA

    1. XR_008486943.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152619.1: Suppressed sequence

      Description
      NM_152619.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N568.4 GenPept UniProtKB/Swiss-Prot:Q8N568

    Gene LinkOut

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