fbp1a fructose-1,6-bisphosphatase 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fbp1aprovided by ZNC
Official Full Name: fructose-1,6-bisphosphatase 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-7171
See related: Ensembl:ENSDARG00000021366 AllianceGenome:ZFIN:ZDB-GENE-030131-7171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fbp1; fbp1l; fk92h02; zgc:64096; wu:fk92h02
Summary: Predicted to enable fructose 1,6-bisphosphate 1-phosphatase activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process; fructose 6-phosphate metabolic process; and hexose metabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in cytosol. Is expressed in female organism; intestine; lens; liver; and solid lens vesicle. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (44833313..44843738, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (44233160..44243585, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fructose-1,6-bisphosphatase 1a

Names: fructose-1,6-bisphosphatase 1, like

NP_956236.1

EC 3.1.3.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199942.2 → NP_956236.1 fructose-1,6-bisphosphatase 1a

See identical proteins and their annotated locations for NP_956236.1

Status: VALIDATED

Source sequence(s)

CR388096, EH585004

UniProtKB/TrEMBL

A0A8N1TXV4, Q6PFT1

Related

ENSDARP00000004866.7, ENSDART00000003926.8

Conserved Domains (1) summary

cd00354
Location:18 → 332

FBPase; Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1, ...