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    emc4 ER membrane protein complex subunit 4 [ Danio rerio (zebrafish) ]

    Gene ID: 402956, updated on 9-Dec-2024

    Summary

    Official Symbol
    emc4provided by ZNC
    Official Full Name
    ER membrane protein complex subunit 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1891
    See related
    Ensembl:ENSDARG00000039268 AllianceGenome:ZFIN:ZDB-GENE-040426-1891
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem85; zgc:77852
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC4 (ER membrane protein complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
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    Genomic context

    See emc4 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (1457379..1468521)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (1321389..1332441)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 6 Neighboring gene cylindromatosis (turban tumor syndrome) 3 Neighboring gene uncharacterized LOC137496114 Neighboring gene lysophosphatidylcholine acyltransferase 4 Neighboring gene uncharacterized LOC137496113

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC77852

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tail-anchored membrane protein insertion into ER membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EMC complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ER membrane protein complex subunit 4
    Names
    transmembrane protein 85

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_205658.1NP_991221.1  ER membrane protein complex subunit 4

      See identical proteins and their annotated locations for NP_991221.1

      Status: PROVISIONAL

      Source sequence(s)
      BC065880
      UniProtKB/Swiss-Prot
      Q6P011
      Related
      ENSDARP00000142500.1, ENSDART00000173433.2
      Conserved Domains (1) summary
      pfam06417
      Location:62176
      DUF1077; Protein of unknown function (DUF1077)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      1457379..1468521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)