U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    epha4b eph receptor A4b [ Danio rerio (zebrafish) ]

    Gene ID: 64270, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    epha4bprovided by ZNC
    Official Full Name
    eph receptor A4bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030826-6
    See related
    Ensembl:ENSDARG00000011600 AllianceGenome:ZFIN:ZDB-GENE-030826-6
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    rtk2; EphA3; epha4; id:ibd2782
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within negative regulation of axon extension; negative regulation of collateral sprouting of intact axon in response to injury; and regulation of myelination. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including axis; immature eye; intestinal bulb primordium; nervous system; and pharyngeal arch. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See epha4b in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (40294313..40514151)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (40424222..40660467)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 34a, duplicate 4 Neighboring gene uncharacterized LOC137488023 Neighboring gene chemokine (C motif) ligand 32a, duplicate 1 Neighboring gene uncharacterized LOC137488024 Neighboring gene uncharacterized LOC137487481

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Specification and morphogenesis of the zebrafish larval head skeleton. Kimmel CB, et al. Dev Biol, 2001 May 15. PMID 11336493
    2. Axis-inducing activities and cell fates of the zebrafish organizer. Saúde L, et al. Development, 2000 Aug. PMID 10903167
    3. The role of the Eph-ephrin signalling system in the regulation of developmental patterning. Coulthard MG, et al. Int J Dev Biol, 2002. PMID 12141423
    4. Retinotopic order in the absence of axon competition. Gosse NJ, et al. Nature, 2008 Apr 17. PMID 18368050, Free PMC Article
    5. Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint. Miller CT, et al. Development, 2003 Apr. PMID 12588851

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EPHA6, a gene implicated in retinal axon guidance, is one of HMX1 targets in eye development.
      Title: A dimerized HMX1 inhibits EPHA6/epha4b in mouse and zebrafish retinas.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of collateral sprouting of intact axon in response to injury IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    ephrin type-A receptor 4b
    Names
    eph-like receptor tyrosine kinase 2
    NP_705944.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153658.1 → NP_705944.1  ephrin type-A receptor 4b precursor

      See identical proteins and their annotated locations for NP_705944.1

      Status: PROVISIONAL

      Source sequence(s)
      AF369381
      UniProtKB/TrEMBL
      Q90ZN9
      Related
      ENSDARP00000030606.8, ENSDART00000037292.9
      Conserved Domains (7) summary
      cd09488
      Location:907 → 967
      SAM_EPH-R; SAM domain of EPH family of tyrosine kinase receptors
      smart00454
      Location:907 → 967
      SAM; Sterile alpha motif
      cd10473
      Location:31 → 203
      EphR_LBD_A; Ligand Binding Domain of Ephrin type-A Receptors
      cd00063
      Location:447 → 526
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd05066
      Location:617 → 883
      PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
      pfam07714
      Location:622 → 879
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:546 → 617
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      40294313..40514151
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous