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    slc25a39 solute carrier family 25 member 39 [ Danio rerio (zebrafish) ]

    Gene ID: 393458, updated on 9-Dec-2024

    Summary

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    Official Symbol
    slc25a39provided by ZNC
    Official Full Name
    solute carrier family 25 member 39provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1250
    See related
    Ensembl:ENSDARG00000007449 AllianceGenome:ZFIN:ZDB-GENE-040426-1250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:63736
    Summary
    Predicted to enable 2 iron, 2 sulfur cluster binding activity and metallochaperone activity. Acts upstream of or within heme biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in intermediate cell mass of mesoderm and nucleate erythrocyte. Orthologous to human SLC25A39 (solute carrier family 25 member 39). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See slc25a39 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (29872818..29891464, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (29741976..29760653, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA54 Neighboring gene small nucleolar RNA U83B Neighboring gene ribosomal protein L3 Neighboring gene ribosomal protein L27 Neighboring gene RUN domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Nilsson R, et al. Cell Metab, 2009 Aug. PMID 19656490, Free PMC Article
    2. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
    3. Expression and regulation of drug transporters in vertebrate neutrophils. Foulkes MJ, et al. Sci Rep, 2017 Jul 10. PMID 28694436, Free PMC Article
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for functional heme biosynthesis in erythroid cells. Possibly regulate ALAS2 through iron-sulfur cluster biogenesis.
      Title: Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC63736

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallochaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione import into mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within manganese ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial glutathione transporter SLC25A39
    Names
    probable mitochondrial glutathione transporter SLC25A39

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200486.1 → NP_956780.1  mitochondrial glutathione transporter SLC25A39

      See identical proteins and their annotated locations for NP_956780.1

      Status: PROVISIONAL

      Source sequence(s)
      BC055226
      UniProtKB/Swiss-Prot
      Q7SXW0
      Related
      ENSDARP00000005911.6, ENSDART00000014021.8
      Conserved Domains (1) summary
      pfam00153
      Location:250 → 351
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      29872818..29891464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005163931.5 → XP_005163988.1  mitochondrial glutathione transporter SLC25A39 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BB72
      Conserved Domains (2) summary
      PTZ00169
      Location:20 → 319
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:13 → 133
      Mito_carr; Mitochondrial carrier protein

    2. XM_005163930.5 → XP_005163987.1  mitochondrial glutathione transporter SLC25A39 isoform X3

      UniProtKB/TrEMBL
      A0A8M2BB41
      Conserved Domains (2) summary
      PTZ00169
      Location:20 → 320
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:13 → 133
      Mito_carr; Mitochondrial carrier protein

    3. XM_005163929.5 → XP_005163986.1  mitochondrial glutathione transporter SLC25A39 isoform X2

      UniProtKB/TrEMBL
      A0A8M2BBF8
      Conserved Domains (1) summary
      pfam00153
      Location:163 → 246
      Mito_carr; Mitochondrial carrier protein

    4. XM_021469806.2 → XP_021325481.1  mitochondrial glutathione transporter SLC25A39 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PT31, F1QVQ4
      Conserved Domains (1) summary
      pfam00153
      Location:250 → 351
      Mito_carr; Mitochondrial carrier protein

    5. XM_068216183.1 → XP_068072284.1  mitochondrial glutathione transporter SLC25A39 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PT31, F1QVQ4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7SXW0.1 GenPept UniProtKB/Swiss-Prot:Q7SXW0

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