pcna proliferating cell nuclear antigen [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pcnaprovided by ZNC
Official Full Name: proliferating cell nuclear antigenprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000210-8
See related: Ensembl:ENSDARG00000054155 AllianceGenome:ZFIN:ZDB-GENE-000210-8
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb16; fa28e03; fb36g03; wu:fa28e03; wu:fb36g03
Summary: Predicted to enable DNA polymerase processivity factor activity. Acts upstream of or within response to activity and response to bacterium. Located in nucleus. Is expressed in several structures, including anterior neural tube; head; immature eye; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in ataxia-telangiectasia-like disorder-2. Orthologous to human PCNA (proliferating cell nuclear antigen). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (40821804..40826678, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (40900618..40905492, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of telomerase activity and TERT in retina implies that telomerase has functions other than the elongation of telomere. These findings could provide new insights on telomerase function in the nervous system.
Title: Molecular cloning and characterization of the zebrafish (Danio rerio) telomerase catalytic subunit (telomerase reverse transcriptase, TERT).
intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1, p21, PCNA and cdk2, but only weakly influences cyclin B1, cyclin B2 and cyclin E1 expression.
Title: Circadian clock regulation of the cell cycle in the zebrafish intestine.

Submit: New GeneRIF Correction

General gene information

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Markers

AA606219 (e-PCR)
- UniSTS:206863

aa606219 (e-PCR)
- UniSTS:186913

fb36g03.x1 (e-PCR)
- UniSTS:203149

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase processivity factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
involved_in leading strand elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mismatch repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of PCNA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PCNA-p21 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proliferating cell nuclear antigen

Names: etID36690.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131404.2 → NP_571479.2 proliferating cell nuclear antigen

See identical proteins and their annotated locations for NP_571479.2

Status: VALIDATED

Source sequence(s)

BC064299, EH446205

UniProtKB/Swiss-Prot

Q7ZW84, Q9PTP1

Related

ENSDARP00000070780.3, ENSDART00000076304.5

Conserved Domains (2) summary

cd00577
Location:4 → 256

PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...

TIGR00590
Location:1 → 258

pcna; proliferating cell nuclear antigen (pcna)