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    psap prosaposin [ Danio rerio (zebrafish) ]

    Gene ID: 140811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    psapprovided by ZNC
    Official Full Name
    prosaposinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020108-1
    See related
    Ensembl:ENSDARG00000013968 AllianceGenome:ZFIN:ZDB-GENE-020108-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cb759; wu:fa14a06; wu:fb36e02; wu:fb58g07
    Summary
    Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; regulation of lipid metabolic process; and sphingolipid metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in extracellular region and lysosome. Is expressed in blood; extension; peripheral olfactory organ; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in atypical Gaucher's disease due to saposin c deficiency; combined saposin deficiency; and late onset Parkinson's disease. Orthologous to several human genes including PSAP (prosaposin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See psap in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (5004934..5029013)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (4876321..4900427)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene mitochondrial ribosomal protein S6 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2c Neighboring gene solute carrier family 29 member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Prosaposin maintains adult neural stem cells in a state associated with deep quiescence. Labusch M, et al. Stem Cell Reports, 2024 Apr 9. PMID 38518783, Free PMC Article
    2. Conservation of expression and alternative splicing in the prosaposin gene. Cohen T, et al. Brain Res Mol Brain Res, 2004 Oct 22. PMID 15469878
    3. The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates. Hazkani-Covo E, et al. J Mol Evol, 2002 Jan. PMID 11734895
    4. Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish. Godfrey A, et al. Aquat Toxicol, 2017 Dec. PMID 29101780
    5. Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis. Newman M, et al. J Alzheimers Dis, 2009. PMID 19158429

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prosaposin maintains adult neural stem cells in a state associated with deep quiescence.
      Title: Prosaposin maintains adult neural stem cells in a state associated with deep quiescence.
    2. reconstruction of the order of internal duplications that gave rise to the four saposins by using phylogenetic tools
      Title: The evolutionary history of prosaposin: two successive tandem-duplication events gave rise to the four saposin domains in vertebrates.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    prosaposin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309267.1 → NP_001296196.1  prosaposin isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      CR388420, DT076525, EH448860, EH456725, EH494304, EH520630, EH545656
      UniProtKB/TrEMBL
      A0A8M1P746, B8JI17
      Related
      ENSDARP00000056294.6, ENSDART00000056295.8
      Conserved Domains (5) summary
      smart00162
      Location:19 → 52
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:312 → 385
      SapB; Saposin (B) Domains
      pfam02199
      Location:489 → 518
      SapA; Saposin A-type domain
      pfam03489
      Location:354 → 385
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:312 → 346
      SapB_1; Saposin-like type B, region 1

    2. NM_131883.2 → NP_571958.2  prosaposin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      CR388420, DT076525, EH448860, EH456725, EH520630, EH545656
      UniProtKB/TrEMBL
      A0A8M1P781, E7FCT1
      Related
      ENSDARP00000106362.2, ENSDART00000130379.3
      Conserved Domains (5) summary
      smart00162
      Location:19 → 52
      SAPA; Saposin/surfactant protein-B A-type DOMAIN
      smart00741
      Location:314 → 387
      SapB; Saposin (B) Domains
      pfam02199
      Location:491 → 520
      SapA; Saposin A-type domain
      pfam03489
      Location:356 → 387
      SapB_2; Saposin-like type B, region 2
      pfam05184
      Location:314 → 348
      SapB_1; Saposin-like type B, region 1

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      5004934..5029013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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