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    afg3l2 AFG3-like AAA ATPase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 569168, updated on 9-Dec-2024

    Summary

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    Official Symbol
    afg3l2provided by ZNC
    Official Full Name
    AFG3-like AAA ATPase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-46
    See related
    Ensembl:ENSDARG00000062272 AllianceGenome:ZFIN:ZDB-GENE-070912-46
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-12e1.4
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in mitochondrial protein processing. Predicted to act upstream of or within proteolysis. Predicted to be located in membrane. Predicted to be part of m-AAA complex. Human ortholog(s) of this gene implicated in optic atrophy 12; spastic ataxia; spastic ataxia 5; and spinocerebellar ataxia type 28. Orthologous to human AFG3L2 (AFG3 like matrix AAA peptidase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See afg3l2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (21452822..21469900)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (21794760..21811838)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like b Neighboring gene microRNA 26a-2 Neighboring gene phospholipase C, delta 1b Neighboring gene uncharacterized LOC108179685 Neighboring gene inhibin subunit beta Ab Neighboring gene M-phase specific PLK1 interacting protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
    2. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of m-AAA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial inner membrane m-AAA protease component AFG3L2
    Names
    AFG3 ATPase family gene 3-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111197.1 → NP_001104667.1  mitochondrial inner membrane m-AAA protease component AFG3L2

      See identical proteins and their annotated locations for NP_001104667.1

      Status: PROVISIONAL

      Source sequence(s)
      BC155655
      UniProtKB/TrEMBL
      A0A0R4IUQ8, A0A8M1NEZ0, A9JRG9
      Related
      ENSDARP00000138163.2, ENSDART00000169028.2
      Conserved Domains (4) summary
      TIGR01241
      Location:248 → 741
      FtsH_fam; ATP-dependent metalloprotease FtsH
      pfam00004
      Location:340 → 471
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam01434
      Location:557 → 739
      Peptidase_M41; Peptidase family M41
      pfam06480
      Location:141 → 237
      FtsH_ext; FtsH Extracellular

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      21452822..21469900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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