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    slmapa sarcolemma associated protein a [ Danio rerio (zebrafish) ]

    Gene ID: 572011, updated on 2-Nov-2024

    Summary

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    Official Symbol
    slmapaprovided by ZNC
    Official Full Name
    sarcolemma associated protein aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-184
    See related
    Ensembl:ENSDARG00000054458 AllianceGenome:ZFIN:ZDB-GENE-061013-184
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fa03e05; fb39b03; wu:fa03e05; wu:fb39b03; zgc:153887
    Summary
    Predicted to be involved in negative regulation of hippo signaling and regulation of membrane depolarization during cardiac muscle cell action potential. Predicted to be located in membrane. Orthologous to human SLMAP (sarcolemma associated protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See slmapa in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (42305549..42418380, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (42036675..42148441, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911880 Neighboring gene filamin B, like Neighboring gene uncharacterized LOC137496736 Neighboring gene DENN/MADD domain containing 6Aa Neighboring gene ADP-ribosylation factor 4b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Decellularized zebrafish cardiac extracellular matrix induces mammalian heart regeneration. Chen WC, et al. Sci Adv, 2016 Nov. PMID 28138518, Free PMC Article
    2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in negative regulation of hippo signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane depolarization during cardiac muscle cell action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sarcolemma associated protein a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077254.1 → NP_001070722.1  sarcolemma associated protein a

      See identical proteins and their annotated locations for NP_001070722.1

      Status: PROVISIONAL

      Source sequence(s)
      BC124763
      UniProtKB/TrEMBL
      A0A8M1NB23, Q08BE3
      Related
      ENSDARP00000138370.1, ENSDART00000160704.2
      Conserved Domains (5) summary
      COG1716
      Location:46 → 109
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:14 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:163 → 793
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17023
      Location:287 → 475
      DUF5098; Domain of unknown function (DUF5098)
      cl19219
      Location:297 → 367
      DUF342; Protein of unknown function (DUF342)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      42305549..42418380 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224212.1 → XP_068080313.1  sarcolemma associated protein a isoform X5

      Related
      ENSDARP00000095217.4, ENSDART00000104444.4

    2. XM_005168061.5 → XP_005168118.1  sarcolemma associated protein a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BFG9
      Conserved Domains (5) summary
      COG1716
      Location:46 → 109
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:14 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:163 → 814
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17023
      Location:287 → 496
      DUF5098; Domain of unknown function (DUF5098)
      cl19219
      Location:297 → 367
      DUF342; Protein of unknown function (DUF342)

    3. XM_005168063.5 → XP_005168120.1  sarcolemma associated protein a isoform X4

      UniProtKB/TrEMBL
      A0A8M2BFI3
      Conserved Domains (4) summary
      COG1716
      Location:46 → 109
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:14 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:163 → 776
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl19219
      Location:297 → 367
      DUF342; Protein of unknown function (DUF342)

    4. XM_005168062.5 → XP_005168119.1  sarcolemma associated protein a isoform X3

      UniProtKB/TrEMBL
      A0A8M2BFH7
      Conserved Domains (5) summary
      COG1716
      Location:46 → 109
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:14 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:163 → 793
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17023
      Location:287 → 475
      DUF5098; Domain of unknown function (DUF5098)
      cl19219
      Location:297 → 367
      DUF342; Protein of unknown function (DUF342)

    5. XM_005168060.5 → XP_005168117.1  sarcolemma associated protein a isoform X1

      UniProtKB/TrEMBL
      A0A2R8QQ99, A0A8M2BG26
      Related
      ENSDARP00000155262.1, ENSDART00000191086.1
      Conserved Domains (5) summary
      COG1716
      Location:46 → 109
      FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
      cd00060
      Location:14 → 108
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      TIGR02168
      Location:163 → 814
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17023
      Location:287 → 496
      DUF5098; Domain of unknown function (DUF5098)
      cl19219
      Location:297 → 367
      DUF342; Protein of unknown function (DUF342)

    6. XM_005168064.5 → XP_005168121.1  sarcolemma associated protein a isoform X6

      UniProtKB/TrEMBL
      A0A8M2BFI9
      Conserved Domains (2) summary
      TIGR02168
      Location:4 → 655
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cl19219
      Location:138 → 208
      DUF342; Protein of unknown function (DUF342)
    Nucleotide Protein Strain
    Heading Accession and Version

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