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    zbtb12.2 zinc finger and BTB domain containing 12, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 559081, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zbtb12.2provided by ZNC
    Official Full Name
    zinc finger and BTB domain containing 12, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-27
    See related
    Ensembl:ENSDARG00000070658 AllianceGenome:ZFIN:ZDB-GENE-060503-27
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:ch211-222e23.7
    Summary
    Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZBTB12 (zinc finger and BTB domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See zbtb12.2 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (26956736..26964342, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (27370960..27380144, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene negative elongation factor complex member E Neighboring gene zinc finger and BTB domain containing 12, tandem duplicate 1 Neighboring gene SAC1 like phosphatidylinositide phosphatase a Neighboring gene tumor necrosis factor a (TNF superfamily, member 2)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 12.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044884.1 → NP_001038349.1  zinc finger and BTB domain-containing protein 12.2

      See identical proteins and their annotated locations for NP_001038349.1

      Status: PROVISIONAL

      Source sequence(s)
      BX537337
      UniProtKB/TrEMBL
      B7ZVC6, F6P148, Q1LWQ5
      Related
      ENSDARP00000094731.3, ENSDART00000103955.5
      Conserved Domains (5) summary
      smart00225
      Location:32 → 126
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:422 → 525
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:437 → 457
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:435 → 457
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 123
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      26956736..26964342 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170045.4 → XP_005170102.1  zinc finger and BTB domain-containing protein 12.2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHD2
      Conserved Domains (5) summary
      smart00225
      Location:32 → 125
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:421 → 524
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:436 → 456
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:434 → 456
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:21 → 122
      BTB; BTB/POZ domain
    Nucleotide Protein
    Heading Accession and Version

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