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    mical3a microtubule associated monooxygenase, calponin and LIM domain containing 3a [ Danio rerio (zebrafish) ]

    Gene ID: 402881, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mical3aprovided by ZNC
    Official Full Name
    microtubule associated monooxygenase, calponin and LIM domain containing 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050126-2
    See related
    Ensembl:ENSDARG00000097017 AllianceGenome:ZFIN:ZDB-GENE-050126-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mical3; MICAL-3A
    Summary
    Predicted to enable FAD binding activity; actin binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen. Predicted to be involved in actin filament depolymerization. Predicted to act upstream of or within exocytosis. Predicted to be located in nucleus. Is expressed in several structures, including cardiovascular system; pectoral fin; pectoral fin bud; proctodeum; and retina. Orthologous to human MICAL3 (microtubule associated monooxygenase, calponin and LIM domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mical3a in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    50
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (10771179..10924469)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (10748525..10955740)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene leptin a Neighboring gene RNA binding motif protein 28 Neighboring gene tetratricopeptide repeat domain 38 Neighboring gene tetraspanin 33b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Identification and expression analysis of mical family genes in zebrafish. Xue Y, et al. J Genet Genomics, 2010 Oct. PMID 21035094
    2. Functional validation of GWAS gene candidates for abnormal liver function during zebrafish liver development. Liu LY, et al. Dis Model Mech, 2013 Sep. PMID 23813869, Free PMC Article
    3. Eumetazoan cryptochrome phylogeny and evolution. Haug MF, et al. Genome Biol Evol, 2015 Jan 18. PMID 25601102, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables F-actin monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein-methionine sulfoxide oxidase mical3a
    Names
    flavoprotein oxidoreductase MICAL3
    microtubule associated monoxygenase, calponin and LIM domain containing 3a
    molecule interacting with CasL protein 3A
    XP_021323436.1
    XP_021323437.1
    XP_021328912.1
    XP_021328913.1
    XP_021328914.1
    XP_068070979.1
    XP_068070980.1
    XP_068070981.1
    XP_068070982.1
    XP_068074994.1
    XP_068074995.1
    XP_068074996.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      10771179..10924469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068214878.1 → XP_068070979.1  protein-methionine sulfoxide oxidase mical3a isoform X1

    2. XM_068214879.1 → XP_068070980.1  protein-methionine sulfoxide oxidase mical3a isoform X2

      Related
      ENSDARP00000136331.1, ENSDART00000161990.2

    3. XM_068214880.1 → XP_068070981.1  protein-methionine sulfoxide oxidase mical3a isoform X3

    4. XM_021467761.2 → XP_021323436.1  protein-methionine sulfoxide oxidase mical3a isoform X4

      UniProtKB/Swiss-Prot
      F1QH17, Q1LWQ6, Q6PBR2
      UniProtKB/TrEMBL
      A0A8M9PME7
      Conserved Domains (7) summary
      cd09439
      Location:774 → 828
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:527 → 627
      CH; Calponin homology (CH) domain
      pfam12130
      Location:2006 → 2140
      DUF3585; Protein of unknown function (DUF3585)
      cl25496
      Location:1176 → 1491
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25751
      Location:1528 → 1584
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1647 → 2141
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27552
      Location:91 → 239
      FAD_binding_3; FAD binding domain

    5. XM_021467762.2 → XP_021323437.1  protein-methionine sulfoxide oxidase mical3a isoform X5

      UniProtKB/Swiss-Prot
      F1QH17, Q1LWQ6, Q6PBR2
      UniProtKB/TrEMBL
      A0A8M9PVP9
      Conserved Domains (7) summary
      cd09439
      Location:774 → 828
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:527 → 627
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1976 → 2110
      DUF3585; Protein of unknown function (DUF3585)
      cl25496
      Location:1146 → 1461
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25751
      Location:1498 → 1554
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1617 → 2111
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27552
      Location:91 → 239
      FAD_binding_3; FAD binding domain

    6. XM_068214881.1 → XP_068070982.1  protein-methionine sulfoxide oxidase mical3a isoform X6

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395007.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      397..95364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473237.1 → XP_021328912.1  protein-methionine sulfoxide oxidase mical3a isoform X7

      UniProtKB/TrEMBL
      A0A8M9PCY4
      Conserved Domains (7) summary
      cd09439
      Location:1086 → 1140
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:536 → 636
      CH; Calponin homology (CH) domain
      pfam12130
      Location:2318 → 2508
      DUF3585; Protein of unknown function (DUF3585)
      cl25496
      Location:1488 → 1803
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25732
      Location:2220 → 2506
      SMC_N; RecF/RecN/SMC N terminal domain
      cl25751
      Location:1840 → 1896
      DUF4045; Domain of unknown function (DUF4045)
      cl27552
      Location:91 → 239
      FAD_binding_3; FAD binding domain

    2. XM_068218893.1 → XP_068074994.1  protein-methionine sulfoxide oxidase mical3a isoform X8

    3. XM_068218894.1 → XP_068074995.1  protein-methionine sulfoxide oxidase mical3a isoform X9

    4. XM_021473238.1 → XP_021328913.1  protein-methionine sulfoxide oxidase mical3a isoform X10

      UniProtKB/Swiss-Prot
      F1QH17, Q1LWQ6, Q6PBR2
      UniProtKB/TrEMBL
      A0A8M9PME7
      Conserved Domains (7) summary
      cd09439
      Location:774 → 828
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:527 → 627
      CH; Calponin homology (CH) domain
      pfam12130
      Location:2006 → 2140
      DUF3585; Protein of unknown function (DUF3585)
      cl25496
      Location:1176 → 1491
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25751
      Location:1528 → 1584
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1647 → 2141
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27552
      Location:91 → 239
      FAD_binding_3; FAD binding domain

    5. XM_021473239.1 → XP_021328914.1  protein-methionine sulfoxide oxidase mical3a isoform X11

      UniProtKB/Swiss-Prot
      F1QH17, Q1LWQ6, Q6PBR2
      UniProtKB/TrEMBL
      A0A8M9PVP9
      Conserved Domains (7) summary
      cd09439
      Location:774 → 828
      LIM_Mical; The LIM domain of Mical (molecule interacting with CasL)
      pfam00307
      Location:527 → 627
      CH; Calponin homology (CH) domain
      pfam12130
      Location:1976 → 2110
      DUF3585; Protein of unknown function (DUF3585)
      cl25496
      Location:1146 → 1461
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      cl25751
      Location:1498 → 1554
      DUF4045; Domain of unknown function (DUF4045)
      cl26511
      Location:1617 → 2111
      Neuromodulin_N; Gap junction protein N-terminal region
      cl27552
      Location:91 → 239
      FAD_binding_3; FAD binding domain

    6. XM_068218895.1 → XP_068074996.1  protein-methionine sulfoxide oxidase mical3a isoform X12

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1QH17.2 GenPept UniProtKB/Swiss-Prot:F1QH17

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