unga uracil DNA glycosylase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ungaprovided by ZNC
Official Full Name: uracil DNA glycosylase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-900
See related: Ensembl:ENSDARG00000042527 AllianceGenome:ZFIN:ZDB-GENE-040426-900
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ung; zgc:56102
Summary: Enables G/U mismatch-specific uracil-DNA glycosylase activity and histone H3K27 methyltransferase activity. Acts upstream of or within negative regulation of heterochromatin formation and positive regulation of DNA-templated transcription. Predicted to be active in mitochondrion and nucleus. Is expressed in blastomere; oocyte stage I; and oocyte stage II. Human ortholog(s) of this gene implicated in dysgammaglobulinemia and immunodeficiency with hyper IgM type 5. Orthologous to human UNG (uracil DNA glycosylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (67351219..67365750, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (66672850..66687381, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results together suggest that Unga is implicated in postfertilization genomic DNA demethylation, zygotic gene transcription, and normal embryonic development in zebrafish.
Title: Uracil-DNA glycosylase is involved in DNA demethylation and required for embryonic development in the zebrafish embryo.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G/U mismatch-specific uracil-DNA glycosylase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone H3K27 methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing N-glycosyl compounds	IEA Inferred from Electronic Annotation more info
enables uracil DNA N-glycosylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uracil-DNA glycosylase

NP_957268.1

EC 3.2.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.