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    elovl1b ELOVL fatty acid elongase 1b [ Danio rerio (zebrafish) ]

    Gene ID: 406725, updated on 2-Nov-2024

    Summary

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    Official Symbol
    elovl1bprovided by ZNC
    Official Full Name
    ELOVL fatty acid elongase 1bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2755
    See related
    Ensembl:ENSDARG00000103735 AllianceGenome:ZFIN:ZDB-GENE-040426-2755
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56567; wu:fj32h05
    Summary
    Predicted to enable fatty acid elongase activity. Acts upstream of or within kidney development and swim bladder development. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including digestive system; fin; nervous system; periderm; and pleuroperitoneal region. Orthologous to human ELOVL1 (ELOVL fatty acid elongase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See elovl1b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (13094173..13152302, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (13036514..13094643, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3-like 4 Neighboring gene zinc finger, FYVE domain containing 9b Neighboring gene MOB kinase activator 3C Neighboring gene MAPK interacting serine/threonine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Metabolic rerouting via SCD1 induction impacts X-linked adrenoleukodystrophy. Raas Q, et al. J Clin Invest, 2021 Apr 15. PMID 33690217, Free PMC Article
    2. C24:0 avoids cold exposure-induced oxidative stress and fatty acid β-oxidation damage. Sun S, et al. iScience, 2021 Dec 17. PMID 34849471, Free PMC Article
    3. The fatty acid chain elongase, Elovl1, is required for kidney and swim bladder development during zebrafish embryogenesis. Bhandari S, et al. Organogenesis, 2016 Apr 2. PMID 27078170, Free PMC Article
    4. The impact of deleting the mitfa gene in zebrafish on the intestinal microbiota community. Chen Q, et al. Gene, 2022 Dec 20. PMID 36075325
    5. Selecting biologically informative genes in co-expression networks with a centrality score. Azuaje FJ. Biol Direct, 2014 Jun 19. PMID 24947308, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid elongase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid elongation, saturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in long-chain fatty-acyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within swim bladder development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within very long-chain fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    elongation of very long chain fatty acids protein 1b
    Names
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1b
    NP_001315523.1
    NP_998581.2
    XP_009304164.1
    XP_009304165.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328594.1 → NP_001315523.1  elongation of very long chain fatty acids protein 1b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR847923, EH505140, EH603421, FQ790218
      UniProtKB/TrEMBL
      A0A0R4IT00, A0A8M1PF52
      Related
      ENSDARP00000147084.1, ENSDART00000181440.1
      Conserved Domains (1) summary
      pfam01151
      Location:28 → 268
      ELO; GNS1/SUR4 family

    2. NM_213416.2 → NP_998581.2  elongation of very long chain fatty acids protein 1b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR847923, EH585991, EH603421, FQ790218
      UniProtKB/TrEMBL
      A0A0R4IT00, A0A8M1PF52
      Related
      ENSDARP00000139034.1, ENSDART00000169052.2
      Conserved Domains (1) summary
      pfam01151
      Location:28 → 268
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      13094173..13152302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009305889.4 → XP_009304164.1  elongation of very long chain fatty acids protein 1b isoform X1

      See identical proteins and their annotated locations for XP_009304164.1

      UniProtKB/TrEMBL
      A0A0R4IT00, A0A8M1PF52
      Related
      ENSDARP00000144796.1, ENSDART00000190120.1
      Conserved Domains (1) summary
      pfam01151
      Location:28 → 268
      ELO; GNS1/SUR4 family

    2. XM_009305890.4 → XP_009304165.1  elongation of very long chain fatty acids protein 1b isoform X1

      See identical proteins and their annotated locations for XP_009304165.1

      UniProtKB/TrEMBL
      A0A0R4IT00, A0A8M1PF52
      Related
      ENSDARP00000151610.1, ENSDART00000184477.1
      Conserved Domains (1) summary
      pfam01151
      Location:28 → 268
      ELO; GNS1/SUR4 family
    Nucleotide Protein Strain
    Heading Accession and Version

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