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    kntc1 kinetochore associated 1 [ Danio rerio (zebrafish) ]

    Gene ID: 497376, updated on 14-Nov-2024

    Summary

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    Official Symbol
    kntc1provided by ZNC
    Official Full Name
    kinetochore associated 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050208-92
    See related
    Ensembl:ENSDARG00000101670 AllianceGenome:ZFIN:ZDB-GENE-050208-92
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:6912223; im:7138629
    Summary
    Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See kntc1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (66433373..66512522)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (65754179..65833414)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene embigin Neighboring gene huntingtin interacting protein 1 related b Neighboring gene uncharacterized LOC110439837 Neighboring gene uncharacterized LOC137495536

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      66433373..66512522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476680.2 → XP_021332355.1  kinetochore-associated protein 1 isoform X4

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M9QEY6
      Conserved Domains (1) summary
      pfam10493
      Location:1588 → 2135
      Rod_C; Rough deal protein C-terminal region

    2. XM_009301982.4 → XP_009300257.2  kinetochore-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M3B017
      Related
      ENSDARP00000133225.1, ENSDART00000170757.2
      Conserved Domains (1) summary
      pfam10493
      Location:1597 → 2144
      Rod_C; Rough deal protein C-terminal region

    3. XM_068221568.1 → XP_068077669.1  kinetochore-associated protein 1 isoform X3

    4. XM_009301984.4 → XP_009300259.2  kinetochore-associated protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IHW6, A0A8M3ASW0
      Conserved Domains (1) summary
      pfam10493
      Location:1596 → 2143
      Rod_C; Rough deal protein C-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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