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    dcn decorin [ Danio rerio (zebrafish) ]

    Gene ID: 64698, updated on 2-Nov-2024

    Summary

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    Official Symbol
    dcnprovided by ZNC
    Official Full Name
    decorinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010102-1
    See related
    Ensembl:ENSDARG00000012066 AllianceGenome:ZFIN:ZDB-GENE-010102-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    DC
    Summary
    Acts upstream of or within cartilage development; chondroitin sulfate proteoglycan metabolic process; and convergent extension involved in axis elongation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including cranial cartilage; epidermis; nervous system; pericardial region; and periderm. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dcn in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (16368762..16406724, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (16379786..16417748, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene keratocan Neighboring gene lumican Neighboring gene uncharacterized LOC103910437 Neighboring gene wu:fc23c09

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A central role for decorin during vertebrate convergent extension. Zoeller JJ, et al. J Biol Chem, 2009 Apr 24. PMID 19211552, Free PMC Article
    2. Identification of Key Genes and Candidated Pathways in Human Autosomal Dominant Polycystic Kidney Disease by Bioinformatics Analysis. Liu D, et al. Kidney Blood Press Res, 2019. PMID 31330507
    3. Znf469 Plays a Critical Role in Regulating Synthesis of ECM: A Zebrafish Model of Brittle Cornea Syndrome. Bao J, et al. Invest Ophthalmol Vis Sci, 2023 May 1. PMID 37256609, Free PMC Article
    4. Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis. Wang G, et al. Nat Commun, 2020 Jun 1. PMID 32483144, Free PMC Article
    5. Exercise-Induced Hypertrophic and Oxidative Signaling Pathways and Myokine Expression in Fast Muscle of Adult Zebrafish. Rovira M, et al. Front Physiol, 2017. PMID 29326600, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Decorin has a critical role during early embryogenesis
      Title: A central role for decorin during vertebrate convergent extension.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chondroitin sulfate proteoglycan metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within convergent extension involved in axis elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    decorin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131697.1 → NP_571772.1  decorin precursor

      See identical proteins and their annotated locations for NP_571772.1

      Status: PROVISIONAL

      Source sequence(s)
      BC044206
      UniProtKB/TrEMBL
      Q803T1
      Related
      ENSDARP00000025940.8, ENSDART00000013085.9
      Conserved Domains (4) summary
      smart00013
      Location:66 → 97
      LRRNT; Leucine rich repeat N-terminal domain
      cd00116
      Location:233 → 326
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:74 → 94
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:233 → 293
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      16368762..16406724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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