egr2a early growth response 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: egr2aprovided by ZNC
Official Full Name: early growth response 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030723-6
See related: Ensembl:ENSDARG00000044098 AllianceGenome:ZFIN:ZDB-GENE-030723-6
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: frb35
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in hindbrain; hindbrain neural keel; and telencephalon. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 17

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (43663469..43677526, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (43672955..43675628, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish gene frb35 encodes a novel zinc finger protein that shares a high homology with Krx-20; the expression domains of frb35 overlap those of krx-20
Title: A novel zinc finger transcription factor resembles krox-20 in structure and in expression pattern in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 SUMO-protein ligase EGR2a

Names: krox-20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328404.2 → NP_001315333.1 E3 SUMO-protein ligase EGR2a isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

BX927349

UniProtKB/TrEMBL

A0A8M1P4S0, E7F266

Related

ENSDARP00000072456.5, ENSDART00000077990.6

Conserved Domains (4) summary

COG5048
Location:321 → 382

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:295 → 317

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:293 → 317

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:337 → 362

zf-H2C2_2; Zinc-finger double domain
NM_001359896.1 → NP_001346825.1 E3 SUMO-protein ligase EGR2a isoform 3

Status: VALIDATED

Source sequence(s)

BX927349

UniProtKB/TrEMBL

A0A8M9PE40

Conserved Domains (4) summary

COG5048
Location:319 → 380

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:293 → 315

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:291 → 315

zf-C2H2; Zinc finger, C2H2 type

pfam11928
Location:89 → 154

DUF3446; Domain of unknown function (DUF3446)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

43663469..43677526 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_183341.1: Suppressed sequence

Description

NM_183341.1: This RefSeq was removed because currently there is insufficient support for the transcript.