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    gmfg glia maturation factor, gamma [ Danio rerio (zebrafish) ]

    Gene ID: 677752, updated on 14-Nov-2024

    Summary

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    Official Symbol
    gmfgprovided by ZNC
    Official Full Name
    glia maturation factor, gammaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060331-89
    See related
    AllianceGenome:ZFIN:ZDB-GENE-060331-89
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:136987
    Summary
    Predicted to enable Arp2/3 complex binding activity; actin binding activity; and growth factor activity. Acts upstream of or within sprouting angiogenesis. Is expressed in blood vessel and head. Orthologous to human GMFG (glia maturation factor gamma). [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    all
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    Genomic context

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    See gmfg in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (47625254..47627782, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (46781898..46784426)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100537681 Neighboring gene arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 Neighboring gene PAF1 homolog, Paf1/RNA polymerase II complex component Neighboring gene StAR related lipid transfer domain containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The expression of glia maturation factors and the effect of glia maturation factor-γ on angiogenic sprouting in zebrafish. Zuo P, et al. Exp Cell Res, 2013 Mar 10. PMID 23333559
    2. Transcriptomics approach to investigate zebrafish heart regeneration. Sleep E, et al. J Cardiovasc Med (Hagerstown), 2010 May. PMID 20179605
    3. Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Li H, et al. Stem Cell Res Ther, 2023 Apr 30. PMID 37122014, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136987

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables Arp2/3 complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament debranching IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin filament debranching IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glia maturation factor gamma

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040047.1 → NP_001035136.1  glia maturation factor gamma

      See identical proteins and their annotated locations for NP_001035136.1

      Status: PROVISIONAL

      Source sequence(s)
      BC114332
      UniProtKB/TrEMBL
      Q24JU9
      Conserved Domains (1) summary
      cd11283
      Location:9 → 130
      ADF_GMF-beta_like; ADF-homology domain of glia maturation factor beta and related proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      47625254..47627782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials