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    snap29 synaptosome associated protein 29 [ Danio rerio (zebrafish) ]

    Gene ID: 553460, updated on 2-Nov-2024

    Summary

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    Official Symbol
    snap29provided by ZNC
    Official Full Name
    synaptosome associated protein 29provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-226
    See related
    Ensembl:ENSDARG00000038518 AllianceGenome:ZFIN:ZDB-GENE-041111-226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc84f09; im:7145101; wu:fc84f09; si:dkey-178e17.4
    Summary
    Predicted to enable SNAP receptor activity and syntaxin binding activity. Acts upstream of or within several processes, including epidermis morphogenesis; neuromuscular process; and pronephros morphogenesis. Predicted to be located in autophagosome membrane and ciliary membrane. Predicted to be part of SNARE complex. Predicted to be active in plasma membrane. Used to study CEDNIK syndrome. Human ortholog(s) of this gene implicated in CEDNIK syndrome. Orthologous to human SNAP29 (synaptosome associated protein 29). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See snap29 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (1839688..1856656)
    105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (1834494..1846773)

    Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene rasGAP-activating-like protein 1 Neighboring gene phosphatidylinositol 4-kinase, catalytic, alpha b Neighboring gene serpin peptidase inhibitor, clade D (heparin cofactor), member 1 Neighboring gene si:dkey-178e17.3 Neighboring gene uncharacterized LOC137496286

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Li Q, et al. Dis Model Mech, 2011 Nov. PMID 21816950, Free PMC Article
    2. A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Mastrodonato V, et al. Sci Rep, 2019 Feb 4. PMID 30718891, Free PMC Article
    3. Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. Lopez-Rivera E, et al. N Engl J Med, 2017 Feb 23. PMID 28121514, Free PMC Article
    4. Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Guna A, et al. J Neurodev Disord, 2015. PMID 26137170, Free PMC Article
    5. Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Campbell PD, et al. Mol Psychiatry, 2023 Sep. PMID 37794116, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The morphological findings are akin to epidermal changes in harlequin ichthyosis and CEDNIK syndrome, autosomal recessive keratinization disorders due to mutations in the ABCA12 and SNAP29 genes, respectively.
      Title: Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pronephros morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptosomal-associated protein 29

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256256.1 → NP_001243185.1  synaptosomal-associated protein 29

      See identical proteins and their annotated locations for NP_001243185.1

      Status: VALIDATED

      Source sequence(s)
      CR788303
      UniProtKB/TrEMBL
      A0A8M1NZG6, F1Q5X0, F1QP00
      Related
      ENSDARP00000116213.1, ENSDART00000143473.3
      Conserved Domains (2) summary
      cd15856
      Location:206 → 263
      SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
      cd15887
      Location:51 → 115
      SNARE_SNAP29N; N-terminal SNARE motif of SNAP29

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007119.7 Reference GRCz11 Primary Assembly

      Range
      1839688..1856656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166739.5 → XP_005166796.1  synaptosomal-associated protein 29 isoform X1

      See identical proteins and their annotated locations for XP_005166796.1

      UniProtKB/TrEMBL
      A0A8M1NZG6, F1Q5X0, F1QP00
      Related
      ENSDARP00000122078.1, ENSDART00000148254.3
      Conserved Domains (2) summary
      cd15856
      Location:206 → 263
      SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
      cd15887
      Location:51 → 115
      SNARE_SNAP29N; N-terminal SNARE motif of SNAP29

    2. XM_005166738.5 → XP_005166795.1  synaptosomal-associated protein 29 isoform X1

      See identical proteins and their annotated locations for XP_005166795.1

      UniProtKB/TrEMBL
      A0A8M1NZG6, F1Q5X0, F1QP00
      Conserved Domains (2) summary
      cd15856
      Location:206 → 263
      SNARE_SNAP29C; C-terminal SNARE motif of SNAP29
      cd15887
      Location:51 → 115
      SNARE_SNAP29N; N-terminal SNARE motif of SNAP29
    Nucleotide Protein
    Heading Accession and Version

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