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    stk33 serine/threonine kinase 33 [ Danio rerio (zebrafish) ]

    Gene ID: 565828, updated on 14-Nov-2024

    Summary

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    Official Symbol
    stk33provided by ZNC
    Official Full Name
    serine/threonine kinase 33provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040724-242
    See related
    Ensembl:ENSDARG00000054318 AllianceGenome:ZFIN:ZDB-GENE-040724-242
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fab03g11; si:ch211-208c6.6
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See stk33 in Genome Data Viewer
    Location:
    chromosome: 7
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (28374947..28403878, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (28103754..28132677, complement)

    Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene LIM domain only 1 Neighboring gene uncharacterized LOC108190676 Neighboring gene RERG/RAS-like b Neighboring gene tripartite motif containing 66

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Chatzopoulou A, et al. Mol Cell Endocrinol, 2017 May 15. PMID 28242321
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 33
    NP_001038554.2
    XP_009301347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045089.2 → NP_001038554.2  serine/threonine-protein kinase 33

      See identical proteins and their annotated locations for NP_001038554.2

      Status: PROVISIONAL

      Source sequence(s)
      BC134849
      UniProtKB/TrEMBL
      A0A8N7UYA5, A4IFZ4, Q5RHZ0
      Related
      ENSDARP00000070968.4, ENSDART00000076496.6
      Conserved Domains (2) summary
      smart00220
      Location:48 → 313
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:46 → 313
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007118.7 Reference GRCz11 Primary Assembly

      Range
      28374947..28403878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009303072.3 → XP_009301347.1  serine/threonine-protein kinase 33 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B118
      Conserved Domains (2) summary
      smart00220
      Location:42 → 307
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:40 → 307
      PKc_like; Protein Kinases, catalytic domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394693.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      76341..105384 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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