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    nle1 notchless homolog 1 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 553606, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nle1provided by ZNC
    Official Full Name
    notchless homolog 1 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-321
    See related
    Ensembl:ENSDARG00000057105 AllianceGenome:ZFIN:ZDB-GENE-050522-321
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fc12b09; fc45f01; wu:fc12b09; wu:fc45f01; zgc:110281
    Summary
    Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in nucleus. Predicted to be active in nucleolus. Is expressed in alar plate midbrain region; nervous system; optic vesicle; and pharyngeal arch. Orthologous to human NLE1 (notchless homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See nle1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (23070752..23099869, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (23101300..23130417, complement)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:dkey-175g6.2 Neighboring gene solute carrier family 25 member 1a Neighboring gene listerin E3 ubiquitin protein ligase 1 Neighboring gene cell adhesion molecule 2a Neighboring gene si:ch73-122g19.1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish midbrain slow-amplifying progenitors exhibit high levels of transcripts for nucleotide and ribosome biogenesis. Recher G, et al. Development, 2013 Dec. PMID 24198278
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC110281

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    notchless protein homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328516.1 → NP_001315445.1  notchless protein homolog 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR926463
      UniProtKB/TrEMBL
      A0A8M1PA49, F1QDT3
      Related
      ENSDARP00000074155.4, ENSDART00000079703.6
      Conserved Domains (5) summary
      smart00320
      Location:436 → 474
      WD40; WD40 repeats
      COG2319
      Location:98 → 474
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:97 → 433
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:8 → 68
      NLE; NLE (NUC135) domain
      sd00039
      Location:150 → 188
      7WD40; WD40 repeat [structural motif]

    2. NM_001328517.1 → NP_001315446.1  notchless protein homolog 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      CR926463
      UniProtKB/TrEMBL
      A0A8M1PA49, F1QDT3
      Related
      ENSDARP00000141676.1, ENSDART00000162444.2
      Conserved Domains (5) summary
      smart00320
      Location:436 → 474
      WD40; WD40 repeats
      COG2319
      Location:98 → 474
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:97 → 433
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam08154
      Location:8 → 68
      NLE; NLE (NUC135) domain
      sd00039
      Location:150 → 188
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      23070752..23099869 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001020582.1: Suppressed sequence

      Description
      NM_001020582.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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