hmx4 H6 family homeobox 4 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hmx4provided by ZNC
Official Full Name: H6 family homeobox 4provided by ZNC
Primary source: ZFIN:ZDB-GENE-060825-142
See related: Ensembl:ENSDARG00000007941 AllianceGenome:ZFIN:ZDB-GENE-060825-142
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Hmx1; soho; wu:fc21b03; zgc:154104
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of retinoic acid biosynthetic process. Predicted to be active in nucleus. Is expressed in brain; immature eye; otic vesicle; and sensory system. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (40909750..40911277, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (40206963..40208538, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hmx4 is a critical regulator of retinoic acid synthesis in a developing embryo, and that this regulation is essential for controlling Shh signaling and forebrain development.
Title: Hmx4 regulates Sonic hedgehog signaling through control of retinoic acid synthesis during forebrain patterning.

Submit: New GeneRIF Correction

General gene information

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Markers

hmx1 (e-PCR)
- UniSTS:205611

fc21b03.x1 (e-PCR)
- UniSTS:203860

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of retinoic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: H6 family homeobox 4

Names: hmx3b; homeobox transcription factor; zfSOHo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001045371.1 → NP_001038836.2 H6 family homeobox 4

Status: PROVISIONAL

Source sequence(s)

BC122454

UniProtKB/TrEMBL

A0A8M1N9F2, B7ZD71

Related

ENSDARP00000010904.6, ENSDART00000027463.7

Conserved Domains (1) summary

pfam00046
Location:115 → 168

Homeobox; Homeobox domain