rhpn2 rhophilin, Rho GTPase binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rhpn2provided by ZNC
Official Full Name: rhophilin, Rho GTPase binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9927
See related: Ensembl:ENSDARG00000014577 AllianceGenome:ZFIN:ZDB-GENE-030131-9927
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb668; sb:cb668; zgc:55960; wu:fa26b12; wu:fk87d04
Summary: Predicted to be involved in negative regulation of stress fiber assembly. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including EVL; axis; nervous system; periderm; and pronephric duct. Orthologous to several human genes including RHPN2 (rhophilin Rho GTPase binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (38349662..38393417)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (38078379..38122159)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA605992 (e-PCR)
- UniSTS:206872

fk87d04.x1 (e-PCR)
- UniSTS:201655

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in negative regulation of stress fiber assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rhophilin-2

Names: GTP-Rho-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201178.1 → NP_957472.1 rhophilin-2

See identical proteins and their annotated locations for NP_957472.1

Status: PROVISIONAL

Source sequence(s)

BC044556

UniProtKB/Swiss-Prot

Q6TNR1, Q803B1

Related

ENSDARP00000024226.6, ENSDART00000010046.8

Conserved Domains (3) summary

cd09249
Location:112 → 496

BRO1_Rhophilin_2; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-2

cd11634
Location:27 → 108

HR1_Rhophilin-2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2

cd00136
Location:524 → 591

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

38349662..38393417

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168961.5 → XP_005169018.1 rhophilin-2 isoform X1

UniProtKB/Swiss-Prot

Q6TNR1, Q803B1

UniProtKB/TrEMBL

A0A8M2BG90

Conserved Domains (3) summary

cd09249
Location:112 → 489

BRO1_Rhophilin_2; Protein-interacting Bro1-like domain of RhoA-binding protein Rhophilin-2

cd11634
Location:27 → 108

HR1_Rhophilin-2; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rhophilin-2

cd00136
Location:514 → 581

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...