hspa8 heat shock protein 8 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hspa8provided by ZNC
Official Full Name: heat shock protein 8provided by ZNC
Primary source: ZFIN:ZDB-GENE-990415-92
See related: Ensembl:ENSDARG00000068992 AllianceGenome:ZFIN:ZDB-GENE-990415-92
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: hsc70; wu:fb01g06; wu:fi48b06
Summary: Predicted to enable several functions, including ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Acts upstream of or within several processes, including fin regeneration; positive regulation of receptor-mediated endocytosis; and protein localization to early endosome. Predicted to be located in lysosome; membrane; and nucleolus. Predicted to be active in several cellular components, including cytosol; lysosomal membrane; and nucleus. Is expressed in several structures, including central nervous system; head; immature eye; presumptive neural plate; and swim bladder. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (29849498..29853710)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (29963158..29967370)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development.
Title: Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development.
Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development.
Title: Genetic deletion of hspa8 leads to selective tissue malformations in zebrafish embryonic development.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fk94d02.x1 (e-PCR)
- UniSTS:201761

fc02g03.x1 (e-PCR)
- UniSTS:192082

fc02g03.x1 (e-PCR)
- UniSTS:192083

MARC_6733-6734:992007355:3 (e-PCR)
- UniSTS:231253

hsp70 (e-PCR), detects polymorphism
- UniSTS:186977

fc74e11.y1 (e-PCR)
- UniSTS:194428

fb01g06.x1 (e-PCR)
- UniSTS:202658

fb61f01.x1 (e-PCR)
- UniSTS:187303

fi48b06.x1 (e-PCR)
- UniSTS:197613

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic camera-type eye development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fin regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to early endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of fibroblast growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heat shock cognate 71 kDa protein

Names: heat shock 70 kDa protein 8; heat shock 70kDa protein 8; heat shock cognate 71-kd protein

NP_001103873.1

EC 3.6.4.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.