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    rhbdl3 rhomboid, veinlet-like 3 (Drosophila) [ Danio rerio (zebrafish) ]

    Gene ID: 550128, updated on 2-Nov-2024

    Summary

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    Official Symbol
    rhbdl3provided by ZNC
    Official Full Name
    rhomboid, veinlet-like 3 (Drosophila)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-2
    See related
    Ensembl:ENSDARG00000105190 AllianceGenome:ZFIN:ZDB-GENE-050417-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    vrho; zgc:113283; si:dkey-10p5.8
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be located in membrane. Is expressed in several structures, including basal plate midbrain region; hatching gland; midbrain neural keel; nervous system; and presumptive diencephalon. Orthologous to human RHBDL3 (rhomboid like 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rhbdl3 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (18623492..18698456, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (22152521..22227150, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene cd7 antigen-like Neighboring gene zinc finger protein 207, b Neighboring gene trinucleotide repeat containing adaptor 6C2 Neighboring gene uncharacterized LOC137495951

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Fine selection of up-regulated genes during ovulation by in vivo induction of oocyte maturation and ovulation in zebrafish. Klangnurak W, et al. Zoological Lett, 2017. PMID 28265462, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    rhomboid-related protein 3
    Names
    ventrhoid transmembrane protein
    NP_001017556.1
    XP_005166241.1
    XP_005166242.1
    XP_005166244.1
    XP_009300624.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017556.2 → NP_001017556.1  rhomboid-related protein 3

      See identical proteins and their annotated locations for NP_001017556.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093439
      UniProtKB/TrEMBL
      A0A0R4IFF3, B2GP95, Q566N3
      Related
      ENSDARP00000134045.1, ENSDART00000166587.2
      Conserved Domains (1) summary
      pfam01694
      Location:107 → 261
      Rhomboid; Rhomboid family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      18623492..18698456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005166185.5 → XP_005166242.1  rhomboid-related protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A0R4IRL0, A0A8M2BDN8
      Related
      ENSDARP00000139086.2, ENSDART00000168554.2
      Conserved Domains (2) summary
      cd00051
      Location:31 → 87
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01694
      Location:200 → 354
      Rhomboid; Rhomboid family

    2. XM_009302349.4 → XP_009300624.1  rhomboid-related protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M3BAC5
      Conserved Domains (3) summary
      cd00051
      Location:35 → 95
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01694
      Location:200 → 354
      Rhomboid; Rhomboid family
      pfam13499
      Location:35 → 94
      EF-hand_7; EF-hand domain pair

    3. XM_005166184.5 → XP_005166241.1  rhomboid-related protein 3 isoform X1

      See identical proteins and their annotated locations for XP_005166241.1

      UniProtKB/TrEMBL
      A0A8M2BDR8, Q2A943
      Related
      ENSDARP00000143289.1, ENSDART00000175205.2
      Conserved Domains (3) summary
      cd00051
      Location:35 → 95
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01694
      Location:208 → 362
      Rhomboid; Rhomboid family
      pfam13499
      Location:35 → 94
      EF-hand_7; EF-hand domain pair

    4. XM_005166187.4 → XP_005166244.1  rhomboid-related protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8M2BDK9
      Conserved Domains (3) summary
      cd00051
      Location:20 → 76
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam01694
      Location:189 → 343
      Rhomboid; Rhomboid family
      pfam13499
      Location:20 → 75
      EF-hand_7; EF-hand domain pair

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394637.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      155770..228387 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395252.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      363705..430641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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