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    nlrc6 NLR family CARD domain containing 6 [ Danio rerio (zebrafish) ]

    Gene ID: 678565, updated on 2-Nov-2024

    Summary

    Official Symbol
    nlrc6provided by ZNC
    Official Full Name
    NLR family CARD domain containing 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-8264
    See related
    Ensembl:ENSDARG00000091320 AllianceGenome:ZFIN:ZDB-GENE-060421-8264
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    NACHT; nlrp12e; zgc:136791
    Summary
    Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 2. Orthologous to human NLRP12 (NLR family pyrin domain containing 12). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See nlrc6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (54766884..54785185)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54089219..54107532)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase type 2 alpha Neighboring gene arginine vasopressin induced 1 Neighboring gene NACHT, LRR and PYD domains-containing protein 12 Neighboring gene si:ch211-196h16.5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General protein information

    Preferred Names
    NACHT, LRR and PYD domains-containing protein 3; uncharacterized protein LOC678565
    Names
    LRR and PYD domains-containing protein 12e
    Nacht 1.01

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      54766884..54785185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160181.5XP_005160238.1  NACHT, LRR and PYD domains-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7E5, A5PF24
      Related
      ENSDARP00000122806.1, ENSDART00000144759.3
      Conserved Domains (5) summary
      COG4886
      Location:660908
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:629930
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00034
      Location:694722
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:128295
      NACHT; NACHT domain
      pfam14484
      Location:47117
      FISNA; Fish-specific NACHT associated domain
    2. XM_068221909.1XP_068078010.1  NACHT, LRR and PYD domains-containing protein 3 isoform X2

    3. XM_021477438.2XP_021333113.1  NACHT, LRR and PYD domains-containing protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8M9Q1B1
      Conserved Domains (4) summary
      sd00034
      Location:665693
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam05729
      Location:128295
      NACHT; NACHT domain
      pfam14484
      Location:47117
      FISNA; Fish-specific NACHT associated domain
      cl26161
      Location:629794
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001040323.1: Suppressed sequence

      Description
      NM_001040323.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: zgc:174180 (GeneID:100008100).