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    sardh sarcosine dehydrogenase [ Danio rerio (zebrafish) ]

    Gene ID: 394103, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sardhprovided by ZNC
    Official Full Name
    sarcosine dehydrogenaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-996
    See related
    Ensembl:ENSDARG00000058102 AllianceGenome:ZFIN:ZDB-GENE-040426-996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:56363
    Summary
    Predicted to enable sarcosine dehydrogenase activity. Predicted to be involved in sarcosine catabolic process. Predicted to be active in mitochondrial matrix. Is expressed in alar plate midbrain region; digestive system; myotome; nervous system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in sarcosinemia. Orthologous to human SARDH (sarcosine dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See sardh in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (10386571..10561822)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (10428312..10603584)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene microRNA 219-1 Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene dopamine beta-hydroxylase (dopamine beta-monooxygenase) Neighboring gene family with sequence similarity 163 member B, genome duplicate a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. COMICS: Cartoon Visualization of Omics Data in Spatial Context Using Anatomical Ontologies. Travin D, et al. J Proteome Res, 2018 Jan 5. PMID 29083911, Free PMC Article
    2. The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. van der Ven LTM, et al. Toxicol Appl Pharmacol, 2020 Nov 15. PMID 32979392
    3. Proteomics of early zebrafish embryos. Link V, et al. BMC Dev Biol, 2006 Jan 13. PMID 16412219, Free PMC Article
    4. Partial depletion of yolk during zebrafish embryogenesis changes the dynamics of methionine cycle and metabolic genes. Huang Y, et al. BMC Genomics, 2015 Jun 4. PMID 26040990, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC56363

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables sarcosine dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sarcosine dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in sarcosine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sarcosine dehydrogenase, mitochondrial
    NP_001313615.1
    XP_005155653.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326686.1 → NP_001313615.1  sarcosine dehydrogenase, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AL935290, BX323065, BX537125
      UniProtKB/TrEMBL
      A0A8M1P859, F1Q5K3
      Related
      ENSDARP00000154120.1, ENSDART00000193875.1
      Conserved Domains (5) summary
      COG0404
      Location:476 → 913
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:60 → 444
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:486 → 795
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:804 → 897
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:427 → 481
      FAO_M; FAD dependent oxidoreductase central domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      10386571..10561822
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005155596.5 → XP_005155653.1  sarcosine dehydrogenase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_005155653.1

      UniProtKB/TrEMBL
      A0A8M1P859, F1Q5K3
      Related
      ENSDARP00000148230.1, ENSDART00000189799.1
      Conserved Domains (5) summary
      COG0404
      Location:476 → 913
      GcvT; Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]
      COG0665
      Location:60 → 444
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      pfam01571
      Location:486 → 795
      GCV_T; Aminomethyltransferase folate-binding domain
      pfam08669
      Location:804 → 897
      GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain
      pfam16350
      Location:427 → 481
      FAO_M; FAD dependent oxidoreductase central domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394772.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      114903..270345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201128.1: Suppressed sequence

      Description
      NM_201128.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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