hells helicase, lymphoid specific [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hellsprovided by ZNC
Official Full Name: helicase, lymphoid specificprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9923
See related: Ensembl:ENSDARG00000057738 AllianceGenome:ZFIN:ZDB-GENE-030131-9923
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb65; pasg; sb:cb65; sb:cb749; im:6911667
Summary: Predicted to enable DNA binding activity; chromatin binding activity; and nucleosome array spacer activity. Acts upstream of or within chromosomal DNA methylation maintenance following DNA replication. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; margin; and pectoral fin musculature. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (8255221..8270717)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (7923198..7938694)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.
Title: Lsh Is Essential for Maintaining Global DNA Methylation Levels in Amphibia and Fish and Interacts Directly with Dnmt1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi26d05.x1 (e-PCR)
- UniSTS:197127

fb72c07.x1 (e-PCR)
- UniSTS:191089

fi46h09.y1 (e-PCR)
- UniSTS:197591

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosomal DNA methylation maintenance following DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lymphoid-specific helicase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037101.1 → NP_001032178.1 lymphoid-specific helicase

See identical proteins and their annotated locations for NP_001032178.1

Status: PROVISIONAL

Source sequence(s)

AY612850

UniProtKB/TrEMBL

Q3BDS6

Related

ENSDARP00000074914.2, ENSDART00000080465.3

Conserved Domains (5) summary

COG0513
Location:605 → 832

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

cd00046
Location:253 → 395

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:236 → 510

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:614 → 728

Helicase_C; Helicase conserved C-terminal domain

pfam07557
Location:518 → 534

Shugoshin_C; Shugoshin C terminus