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    cemip2 cell migration inducing hyaluronidase 2 [ Danio rerio (zebrafish) ]

    Gene ID: 566851, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cemip2provided by ZNC
    Official Full Name
    cell migration inducing hyaluronidase 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-2179
    See related
    Ensembl:ENSDARG00000061600 AllianceGenome:ZFIN:ZDB-GENE-030131-2179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tmem2; fa98g01; fb99a08; wu:fa98g01; wu:fb99a08; si:dkey-24k20.1
    Summary
    Enables hyalurononglucosaminidase activity. Involved in several processes, including heart development; hyaluronan catabolic process; and regulation of signal transduction. Acts upstream of or within heart development; muscle attachment; and positive regulation of extracellular matrix assembly. Located in plasma membrane. Is expressed in brain; cardiovascular system; fin bud; head mesenchyme; and otic vesicle. Orthologous to human CEMIP2 (cell migration inducing hyaluronidase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See cemip2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (25760190..25813615)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (25160006..25213463)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:101016 Neighboring gene abhydrolase domain containing 17B, depalmitoylase Neighboring gene transient receptor potential cation channel, subfamily M, member 3 Neighboring gene uncharacterized LOC137495591 Neighboring gene microRNA 204-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid. Hernandez L, et al. Dev Dyn, 2019 Dec. PMID 31444829, Free PMC Article
    2. A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase. Yamamoto H, et al. J Biol Chem, 2017 May 5. PMID 28246172, Free PMC Article
    3. Tmem2 regulates cell-matrix interactions that are essential for muscle fiber attachment. Ryckebüsch L, et al. Development, 2016 Aug 15. PMID 27471259, Free PMC Article
    4. Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover. De Angelis JE, et al. Dev Cell, 2017 Jan 23. PMID 28118600
    5. The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis. Totong R, et al. Development, 2011 Oct. PMID 21896630, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A model in which hyaluronic acid degradation, regulated by Tmem2, limits the distribution of Wnt signaling and thereby confines the differentiation of the Atrioventricular Canal.
      Title: Tmem2 restricts atrioventricular canal differentiation by regulating degradation of hyaluronic acid.
    2. Tmem2 regulates hyaluronic acid turnover to promote normal Vegf signaling during developmental angiogenesis.
      Title: Tmem2 Regulates Embryonic Vegf Signaling by Controlling Hyaluronic Acid Turnover.
    3. Tmem2 is an essential mediator of myocardium-endocardium coordination during cardiac morphogenesis
      Title: The novel transmembrane protein Tmem2 is essential for coordination of myocardial and endocardial morphogenesis.
    4. immature AVC expansion in wkm mutants is rescued by depleting Bmp4, indicating that Tmem2 restricts bmp4 expression to delimit the AVC primordium during cardiac development
      Title: Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hyalurononglucosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hyalurononglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hyalurononglucosaminidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in atrioventricular valve formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell migration involved in heart formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration to the midline involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryonic heart tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endocardial cushion development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hyaluronan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within hyaluronan catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of extracellular matrix assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of vascular endothelial growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of vascular endothelial growth factor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell surface hyaluronidase
    Names
    frozen ventricle
    frv
    protein frozen ventricle
    protein wickham
    transmembrane protein 2
    NP_001092919.1
    XP_005171957.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099449.1 → NP_001092919.1  cell surface hyaluronidase

      See identical proteins and their annotated locations for NP_001092919.1

      Status: PROVISIONAL

      Source sequence(s)
      BX294191
      UniProtKB/Swiss-Prot
      A3KPQ7
      Related
      ENSDARP00000118976.1, ENSDART00000133217.2
      Conserved Domains (3) summary
      cd13938
      Location:222 → 389
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 246
      G8; G8 domain
      pfam15711
      Location:1239 → 1327
      ILEI; Interleukin-like EMT inducer

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      25760190..25813615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171900.5 → XP_005171957.1  cell surface hyaluronidase isoform X1

      See identical proteins and their annotated locations for XP_005171957.1

      UniProtKB/TrEMBL
      A0A8M2BJ92, G0ZDN6
      Related
      ENSDARP00000082444.4, ENSDART00000088011.7
      Conserved Domains (3) summary
      cd13938
      Location:222 → 389
      PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
      pfam10162
      Location:122 → 246
      G8; G8 domain
      pfam15711
      Location:1251 → 1339
      ILEI; Interleukin-like EMT inducer
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A3KPQ7.1 GenPept UniProtKB/Swiss-Prot:A3KPQ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.