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    naca nascent polypeptide associated complex subunit alpha [ Danio rerio (zebrafish) ]

    Gene ID: 195823, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nacaprovided by ZNC
    Official Full Name
    nascent polypeptide associated complex subunit alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-020423-4
    See related
    Ensembl:ENSDARG00000005513 AllianceGenome:ZFIN:ZDB-GENE-020423-4
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nkn; tdsubc_2b5; unm_t30953; ik:tdsubc_2b5; xx:tdsubc_2b5
    Summary
    Predicted to enable unfolded protein binding activity. Acts upstream of or within definitive hemopoiesis and myofibril assembly. Located in cytoplasm and nucleus. Is expressed in cardiac muscle; caudal hematopoietic tissue; hematopoietic system; skeletal muscle; and somite. Orthologous to several human genes including NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See naca in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (17866008..17874341)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (17939665..17947998)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene Rho family GTPase 1a Neighboring gene DNA primase subunit 1 Neighboring gene tuftelin interacting protein 11 Neighboring gene small nucleolar RNA SNORD59 Neighboring gene small nucleolar RNA SNORD59 Neighboring gene calcium-independent phospholipase A2-gamma-like Neighboring gene neurofascin homolog (chicken) b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization. Li H, et al. FASEB J, 2009 Jun. PMID 19211926
    2. NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation. Murayama E, et al. Nat Commun, 2015 Sep 28. PMID 26411530
    3. RES complex is associated with intron definition and required for zebrafish early embryogenesis. Fernandez JP, et al. PLoS Genet, 2018 Jul. PMID 29969449, Free PMC Article
    4. The important role of apolipoprotein A-II in ezetimibe driven reduction of high cholesterol diet-induced atherosclerosis. Yan Y, et al. Atherosclerosis, 2019 Jan. PMID 30500605
    5. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate that skNAC plays a vital role in myofibril assembly and function during muscle cell differentiation.
      Title: skNAC (skeletal Naca), a muscle-specific isoform of Naca (nascent polypeptide-associated complex alpha), is required for myofibril organization.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nascent polypeptide-associated complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nascent polypeptide-associated complex subunit alpha
    Names
    NAC-alpha
    alpha-NAC
    nascent polypeptide-associated complex alpha polypeptide
    nascent polypeptide-associated complex alpha subunit
    no knack
    sknac
    unm t30953
    NP_001180281.1
    NP_775371.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193352.1 → NP_001180281.1  nascent polypeptide-associated complex subunit alpha isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1), also known as the skeletal naca (sknac) isoform.
      Source sequence(s)
      AY398384, CR381647
      UniProtKB/TrEMBL
      A0A0R4IQN8
      Related
      ENSDARP00000136310.1, ENSDART00000162822.2
      Conserved Domains (3) summary
      COG1308
      Location:889 → 1030
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14415
      Location:984 → 1029
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:890 → 943
      NAC; NAC domain

    2. NM_173264.2 → NP_775371.1  nascent polypeptide-associated complex subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_775371.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AY398384, CR381647
      UniProtKB/Swiss-Prot
      Q0P3U9, Q8JIU7
      UniProtKB/TrEMBL
      B2GPE2
      Related
      ENSDARP00000025953.5, ENSDART00000014723.7
      Conserved Domains (3) summary
      COG1308
      Location:74 → 215
      EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
      cd14415
      Location:169 → 214
      UBA_NACA_NACP1; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and putative NACA-like protein (NACP1)
      pfam01849
      Location:75 → 128
      NAC; NAC domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      17866008..17874341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8JIU7.1 GenPept UniProtKB/Swiss-Prot:Q8JIU7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.