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    deptor DEP domain containing MTOR-interacting protein [ Danio rerio (zebrafish) ]

    Gene ID: 768177, updated on 14-Nov-2024

    Summary

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    Official Symbol
    deptorprovided by ZNC
    Official Full Name
    DEP domain containing MTOR-interacting proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061013-453
    See related
    Ensembl:ENSDARG00000040930 AllianceGenome:ZFIN:ZDB-GENE-061013-453
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    depdc6; fd14h03; fi11e09; wu:fd14h03; wu:fi11e09; zgc:152943
    Summary
    Predicted to be involved in negative regulation of TORC1 signaling and negative regulation of TORC2 signaling. Predicted to act upstream of or within intracellular signal transduction and negative regulation of TOR signaling. Orthologous to human DEPTOR (DEP domain containing MTOR interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See deptor in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (14588104..14675910)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (14697969..14785790)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108179579 Neighboring gene DNA replication and sister chromatid cohesion 1 Neighboring gene collagen, type XIV, alpha 1a Neighboring gene uncharacterized LOC137487886 Neighboring gene uncharacterized LOC137487260 Neighboring gene uncharacterized LOC110437976

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    2. Understanding the complexity of epimorphic regeneration in zebrafish caudal fin tissue: A transcriptomic and proteomic approach. Banu S, et al. Genomics, 2022 Mar. PMID 35134499
    3. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    4. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of TORC2 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DEP domain-containing mTOR-interacting protein
    Names
    DEP domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077320.1 → NP_001070788.2  DEP domain-containing mTOR-interacting protein

      Status: PROVISIONAL

      Source sequence(s)
      BC124609
      UniProtKB/TrEMBL
      A0A8M1NBQ2, Q08BQ7
      Related
      ENSDARP00000140798.2, ENSDART00000167411.2
      Conserved Domains (3) summary
      cd04441
      Location:131 → 215
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:34 → 115
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cl00117
      Location:337 → 364
      PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      14588104..14675910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173524.5 → XP_005173581.1  DEP domain-containing mTOR-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_005173581.1

      UniProtKB/TrEMBL
      A0A8M2BKU4, F1Q589, Q08BQ7
      Related
      ENSDARP00000123498.1, ENSDART00000140469.3
      Conserved Domains (3) summary
      cd00992
      Location:337 → 401
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:131 → 215
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:34 → 115
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.

    2. XM_005173523.5 → XP_005173580.1  DEP domain-containing mTOR-interacting protein isoform X1

      See identical proteins and their annotated locations for XP_005173580.1

      UniProtKB/TrEMBL
      A0A8M2BKU4, F1Q589, Q08BQ7
      Conserved Domains (3) summary
      cd00992
      Location:337 → 401
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd04441
      Location:131 → 215
      DEP_2_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
      cd04442
      Location:34 → 115
      DEP_1_DEP6; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in DEP6-like proteins. DEP6 proteins contain two DEP and a PDZ domain. Their function is unknown.
    Nucleotide Protein
    Heading Accession and Version

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