snx5 sorting nexin 5 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: snx5provided by ZNC
Official Full Name: sorting nexin 5provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2857
See related: Ensembl:ENSDARG00000020442 AllianceGenome:ZFIN:ZDB-GENE-040426-2857
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55769; id:ibd5091; wu:fa66c10; wu:fi28h04
Summary: Predicted to enable dynactin binding activity and phosphatidylinositol binding activity. Acts upstream of or within several processes, including Notch signaling pathway; blood vessel morphogenesis; and retina development in camera-type eye. Located in early endosome. Is expressed in several structures, including cardiovascular system; hematopoietic system; mesoderm; optic tectum; and presumptive blood. Orthologous to human SNX5 (sorting nexin 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33645425..33654884, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33535880..33545339, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SNX5, precisely controlled by miR-216a, is a vital partner of Mib in promoting endocytosis of Delta and subsequent activation of Notch signaling.
Title: miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development.
Snx5, a novel interacting partner of Mind bomb, may have an essential role for cell fate determination in early development.
Title: Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW154441 (e-PCR)
- UniSTS:205911

fa66c10 (e-PCR)
- UniSTS:188837

fi32f08.y1 (e-PCR)
- UniSTS:197290

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pinocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sorting nexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214769.1 → NP_999934.1 sorting nexin-5

See identical proteins and their annotated locations for NP_999934.1

Status: PROVISIONAL

Source sequence(s)

BC044479

UniProtKB/TrEMBL

Q803H8

Related

ENSDARP00000018231.5, ENSDART00000020350.6

Conserved Domains (2) summary

cl02563
Location:24 → 164

PX_domain; The Phox Homology domain, a phosphoinositide binding module

cl12013
Location:180 → 397

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature