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    papss2b 3'-phosphoadenosine 5'-phosphosulfate synthase 2b [ Danio rerio (zebrafish) ]

    Gene ID: 80939, updated on 2-Nov-2024

    Summary

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    Official Symbol
    papss2bprovided by ZNC
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 2bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010323-5
    See related
    Ensembl:ENSDARG00000056600 AllianceGenome:ZFIN:ZDB-GENE-010323-5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Papss1; papss2; sb:cb868; zgc:55851; zgc:85655; id:ibd2761; wu:fb12e05
    Summary
    Predicted to enable adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Predicted to be involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process and sulfate assimilation. Is expressed in several structures, including digestive system; mesoderm; pectoral fin; pectoral fin bud; and sensory system. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See papss2b in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (17458949..17479078, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (17337075..17357204, complement)

    Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene phosphatase and tensin homolog B Neighboring gene ATPase family AAA domain containing 1b Neighboring gene multiple inositol-polyphosphate phosphatase 1b Neighboring gene cytohesin 3a Neighboring gene uncharacterized LOC137496809

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Csrp1 regulates dynamic cell movements of the mesendoderm and cardiac mesoderm through interactions with Dishevelled and Diversin. Miyasaka KY, et al. Proc Natl Acad Sci U S A, 2007 Jul 3. PMID 17592114, Free PMC Article
    2. The TATA-binding protein regulates maternal mRNA degradation and differential zygotic transcription in zebrafish. Ferg M, et al. EMBO J, 2007 Sep 5. PMID 17703193, Free PMC Article
    3. Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Shkumatava A, et al. Genes Dev, 2009 Feb 15. PMID 19240133, Free PMC Article
    4. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b
    Names
    3'-phosphoadenosine 5'-phosphosulfate synthase 2
    NP_997727.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_212562.1 → NP_997727.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2b

      See identical proteins and their annotated locations for NP_997727.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047190
      UniProtKB/TrEMBL
      Q6NV20, Q802U9
      Related
      ENSDARP00000073570.4, ENSDART00000079115.5
      Conserved Domains (3) summary
      cd00517
      Location:243 → 606
      ATPS; ATP-sulfurylase
      cd02027
      Location:43 → 193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:234 → 605
      sopT; ATP sulphurylase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007123.7 Reference GRCz11 Primary Assembly

      Range
      17458949..17479078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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