nusap1 nucleolar and spindle associated protein 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nusap1provided by ZNC
Official Full Name: nucleolar and spindle associated protein 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030827-5
See related: Ensembl:ENSDARG00000002403 AllianceGenome:ZFIN:ZDB-GENE-030827-5
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: YF-9; ankt; fb76a01; fi37a11; sb:cb490; wu:fb76a01; wu:fi37a11
Summary: Predicted to enable microtubule binding activity. Acts upstream of or within neural crest cell migration. Predicted to be located in spindle microtubule. Predicted to be active in mitotic spindle and nucleolus. Is expressed in blood island; nervous system; neural crest; pharyngeal arch 3-7 skeleton; and proliferative region. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33251721..33256681, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33121271..33126231, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

When the in vivo expression of nusap1 was knocked down through antisense oligonucleotide morpholino technology, the morphants of nusap1 showed impaired morphogenesis in the trunk and yolk extension, implying the involvement of Nusap1 in cell migration.
Title: Nusap1 is essential for neural crest cell migration in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fi42h11.x1 (e-PCR)
- UniSTS:204602

fb76a01.x1 (e-PCR)
- UniSTS:187503

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within establishment of mitotic spindle localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nucleolar and spindle-associated protein 1

Names: nuSAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.