rasgef1ba RasGEF domain family, member 1Ba [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rasgef1baprovided by ZNC
Official Full Name: RasGEF domain family, member 1Baprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-5783
See related: Ensembl:ENSDARG00000033614 AllianceGenome:ZFIN:ZDB-GENE-030131-5783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rasgef1b; zgc:66487; wu:fi18a09
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including axis; forerunner cell group; germ ring; mesoderm; and nervous system. Orthologous to human RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (39707311..39805629, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (39107158..39205480, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study showa that three rasgef1b transcripts are generated from two transcriptional start sites and by alternative splicing.
Title: Expression of rasgef1b in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ras-GEF domain-containing family member 1B-A

Names: RasGEF domain family, member 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431104.1 → NP_001418033.1 ras-GEF domain-containing family member 1B-A isoform 1

Status: VALIDATED

Source sequence(s)

AL929533

UniProtKB/TrEMBL

A0A286YBK7, A0A8M2BCQ2

Related

ENSDARP00000144585.1, ENSDART00000176202.2
NM_001431105.1 → NP_001418034.1 ras-GEF domain-containing family member 1B-A isoform 3

Status: VALIDATED

Source sequence(s)

AL929533

Related

ENSDARP00000110368.2, ENSDART00000127123.4
NM_199829.2 → NP_956123.2 ras-GEF domain-containing family member 1B-A isoform 2

Status: VALIDATED

Source sequence(s)

AL929533

UniProtKB/Swiss-Prot

A2AVJ1, Q6DHR3, Q7SXB0

Related

ENSDARP00000116417.1, ENSDART00000137801.2