tlk2 tousled-like kinase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlk2provided by ZNC
Official Full Name: tousled-like kinase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-060623-36
See related: Ensembl:ENSDARG00000010779 AllianceGenome:ZFIN:ZDB-GENE-060623-36
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fi16h09; wu:fi30g12; zgc:136697
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoplasm; cytoskeleton; and nucleoplasm. Predicted to be active in nucleus and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human TLK2 (tousled like kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (19685833..19717932)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (19536060..19568192)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fi16h09.x1 (e-PCR)
- UniSTS:196917

fi30g12.x1 (e-PCR)
- UniSTS:197250

fi68c06.y1 (e-PCR)
- UniSTS:197848

AW174973 (e-PCR)
- UniSTS:205793

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine/threonine-protein kinase tousled-like 2

Names: pKU-alpha protein kinase

NP_001103887.1

EC 2.7.11.1

XP_021325815.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110417.1 → NP_001103887.1 serine/threonine-protein kinase tousled-like 2

See identical proteins and their annotated locations for NP_001103887.1

Status: PROVISIONAL

Source sequence(s)

BC154737

UniProtKB/Swiss-Prot

A8WGJ6, Q1ECX4, Q90ZY7

UniProtKB/TrEMBL

A0A2R8QUZ6

Related

ENSDARP00000003372.7, ENSDART00000006490.9

Conserved Domains (2) summary

smart00220
Location:399 → 666

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:381 → 684

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007114.7 Reference GRCz11 Primary Assembly

Range

19685833..19717932

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021470140.2 → XP_021325815.1 serine/threonine-protein kinase tousled-like 2 isoform X1

UniProtKB/Swiss-Prot

A8WGJ6, Q1ECX4, Q90ZY7

UniProtKB/TrEMBL

A0A8M9PXE3

Conserved Domains (1) summary

cl21453
Location:380 → 683

PKc_like; Protein Kinases, catalytic domain