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    tapbp.1 TAP binding protein (tapasin), tandem duplicate 1 [ Danio rerio (zebrafish) ]

    Gene ID: 30163, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tapbp.1provided by ZNC
    Official Full Name
    TAP binding protein (tapasin), tandem duplicate 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010110-2
    See related
    Ensembl:ENSDARG00000079402 AllianceGenome:ZFIN:ZDB-GENE-010110-2
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tpsn; tapbp; mhc1uda; mhc1ufa; zgc:109814; SI:dZ179B20.1; SI:dZ179B20.3; SI:dZ179B20.7
    Summary
    Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class I. Predicted to be located in membrane. Is expressed in primordial germ cell. Human ortholog(s) of this gene implicated in severe combined immunodeficiency. Orthologous to human TAPBP (TAP binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tapbp.1 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (7038693..7043351, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (7119783..7124421, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 22b Neighboring gene death-domain associated protein Neighboring gene major histocompatibility complex class I UKA Neighboring gene TAP binding protein (tapasin), tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Characterization of the MHC class I region of the Japanese pufferfish (Fugu rubripes). Clark MS, et al. Immunogenetics, 2001. PMID 11220619
    2. Identification of seven genes in the major histocompatibility complex class I region of the zebrafish. Sültmann H, et al. Scand J Immunol, 2000 Jun. PMID 10849368
    3. A contig map of the Mhc class I genomic region in the zebrafish reveals ancient synteny. Michalová V, et al. J Immunol, 2000 May 15. PMID 10799891
    4. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Maddison LA, et al. Mol Genet Genomics, 2009 May. PMID 19221799, Free PMC Article
    5. Characterization of the six zebrafish clade B fibrillar procollagen genes, with evidence for evolutionarily conserved alternative splicing within the pro-alpha1(V) C-propeptide. Hoffman GG, et al. Matrix Biol, 2010 May. PMID 20102740, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TAP binding protein (tapasin), tandem duplicate 1
    Names
    TAP binding protein, tandem duplicate 1
    tapasin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130974.3 → NP_571049.2  TAP binding protein (tapasin), tandem duplicate 1 precursor

      Status: VALIDATED

      Source sequence(s)
      FP085393
      UniProtKB/TrEMBL
      A0A8M2B6H1, Q1LUU3
      Related
      ENSDARP00000095615.4, ENSDART00000104845.6
      Conserved Domains (1) summary
      cl11960
      Location:253 → 381
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      7038693..7043351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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