bmp7a bone morphogenetic protein 7a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: bmp7aprovided by ZNC
Official Full Name: bone morphogenetic protein 7aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-000208-25
See related: Ensembl:ENSDARG00000018260 AllianceGenome:ZFIN:ZDB-GENE-000208-25
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bmp7; fb83f09; wu:fb83f09
Summary: Enables identical protein binding activity and protein heterodimerization activity. Acts upstream of or within several processes, including BMP signaling pathway; determination of bilateral symmetry; and negative regulation of endodermal cell fate specification. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including forebrain; gastrula cell; margin; prechordal plate; and tail bud. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human BMP7 (bone morphogenetic protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (7107798..7139545, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (7099493..7129716, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice.
Title: BMP7 promotes cardiomyocyte regeneration in zebrafish and adult mice.
A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
Title: A tale of two receptors: Bmp heterodimers recruit two type I receptors but use the kinase activity of only one.
BMP heterodimers signal via distinct type I receptor class functions.
Title: BMP heterodimers signal via distinct type I receptor class functions.
these data support a model in which Tfap2a, acting through Bmp7a, modulates Fgf and Notch signaling to control the duration, amount and speed of SAG neural development.
Title: Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.
maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2/7 signaling to establish the initial dorsoventral asymmetry
Title: Maternally supplied Smad5 is required for ventral specification in zebrafish embryos prior to zygotic Bmp signaling.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within determination of ventral identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locus ceruleus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bone morphogenetic protein 7a

Names: bone morphogenetic protein 7; snailhouse; snh

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131321.3 → NP_571396.1 bone morphogenetic protein 7a precursor

See identical proteins and their annotated locations for NP_571396.1

Status: VALIDATED

Source sequence(s)

CR925817, CU633826

UniProtKB/TrEMBL

A0A8N7UZJ1, Q9PTF9

Related

ENSDARP00000017352.7, ENSDART00000016472.9

Conserved Domains (2) summary

pfam00019
Location:329 → 431

TGF_beta; Transforming growth factor beta like domain

pfam00688
Location:34 → 275

TGFb_propeptide; TGF-beta propeptide