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    bmpr1ba bone morphogenetic protein receptor, type IBa [ Danio rerio (zebrafish) ]

    Gene ID: 30742, updated on 14-Nov-2024

    Summary

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    Official Symbol
    bmpr1baprovided by ZNC
    Official Full Name
    bone morphogenetic protein receptor, type IBaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-991208-8
    See related
    Ensembl:ENSDARG00000104100 AllianceGenome:ZFIN:ZDB-GENE-991208-8
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    BR1b; alk6tr; bmpr1b; zALK-6; BMPR-IB; zgc:92220
    Summary
    Predicted to enable SMAD binding activity and transforming growth factor beta receptor activity, type I. Acts upstream of or within BMP signaling pathway and determination of dorsal identity. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; margin; nervous system; optic primordium; and ovarian follicle. Human ortholog(s) of this gene implicated in acromesomelic dysplasia-3; brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See bmpr1ba in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (7488064..7712160, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (6996909..7206866, complement)

    Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137495550 Neighboring gene unc-5 netrin receptor Ca Neighboring gene ras-specific guanine nucleotide-releasing factor RalGPS1-like Neighboring gene angiopoietin-related protein 2 pseudogene Neighboring gene uncharacterized LOC110439803 Neighboring gene PDZ and LIM domain 5a Neighboring gene opsin 4xb

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Maurya AK, et al. Development, 2011 Feb. PMID 21266411
    2. Reduced GS Domain Serine/Threonine Requirements of Fibrodysplasia Ossificans Progressiva Mutant Type I BMP Receptor ACVR1 in the Zebrafish. Allen RS, et al. J Bone Miner Res, 2023 Sep. PMID 37329499, Free PMC Article
    3. BMP2 Is Related to Hirschsprung's Disease and Required for Enteric Nervous System Development. Huang S, et al. Front Cell Neurosci, 2019. PMID 31849612, Free PMC Article
    4. Blood flow and Bmp signaling control endocardial chamber morphogenesis. Dietrich AC, et al. Dev Cell, 2014 Aug 25. PMID 25158852
    5. BMP regulation of myogenesis in zebrafish. Patterson SE, et al. Dev Dyn, 2010 Mar. PMID 20151472, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC92220

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transforming growth factor beta receptor activity, type I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane receptor protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within BMP signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in dorsal/ventral pattern formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bone morphogenetic protein receptor type-1B
    Names
    alk6
    bone morphogenetic protein receptor, type 1b
    bone morphogenetic protein receptor, type 1ba
    NP_571532.1
    XP_021331677.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131457.2 → NP_571532.1  bone morphogenetic protein receptor type-1B precursor

      See identical proteins and their annotated locations for NP_571532.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081625
      UniProtKB/TrEMBL
      Q66HY2, Q9W629
      Related
      ENSDARP00000140548.1, ENSDART00000168820.2
      Conserved Domains (3) summary
      smart00220
      Location:233 → 517
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14219
      Location:226 → 530
      STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
      pfam01064
      Location:61 → 138
      Activin_recp; Activin types I and II receptor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007116.7 Reference GRCz11 Primary Assembly

      Range
      7488064..7712160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476002.2 → XP_021331677.1  bone morphogenetic protein receptor type-1B isoform X1

      UniProtKB/TrEMBL
      A0A8M9PJN6
      Related
      ENSDARP00000132631.1, ENSDART00000158913.2
      Conserved Domains (3) summary
      cd14219
      Location:194 → 498
      STKc_BMPR1b; Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB
      pfam01064
      Location:29 → 102
      Activin_recp; Activin types I and II receptor domain
      pfam08515
      Location:171 → 198
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
    Nucleotide Protein Strain
    Heading Accession and Version

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