selenop2 selenoprotein P2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenop2provided by ZNC
Official Full Name: selenoprotein P2provided by ZNC
Primary source: ZFIN:ZDB-GENE-030311-2
See related: Ensembl:ENSDARG00000079727 AllianceGenome:ZFIN:ZDB-GENE-030311-2
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sePb; SePPb; SelPb; cb689; sepp1b; fb59b06; id:ibd5022; wu:fb59b06
Summary: This gene has a 5-exon structure similar to the paralogous selenoprotein P gene (GeneID:352931). These two genes are thought to have arisen by whole genome duplication. This gene encodes a vertebrate-specific selenoprotein that contains a single selenocysteine (Sec) residue compared to 17 in selenoprotein Pa. The exact function of this selenoprotein is not known; however, it is predicted to have a signal peptide, so it is probably secreted like selenoprotein Pa, and may function as an extracellular antioxidant. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains a single SECIS element compared to two in the mRNA for selenoprotein Pa. [provided by RefSeq, Feb 2018]
Orthologs: all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (27394800..27401117)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (27739166..27745483)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables selenium binding	IBA Inferred from Biological aspect of Ancestor more info
enables selenium binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in selenium compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: selenoprotein Pb

Names: selenoprotein P, 1b; selenoprotein P, plasma, 1b; zSelPb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353911.1 → NP_001340840.1 selenoprotein Pb precursor

Status: REVIEWED

Source sequence(s)

EH498018, EH518168, EH593654

UniProtKB/Swiss-Prot

Q98SV0

Related

ENSDART00000124941.4

Conserved Domains (1) summary

pfam04592
Location:28 → 260

SelP_N; Selenoprotein P, N terminal region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

27394800..27401117

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178298.3: Suppressed sequence

Description

NM_178298.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.