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    FAM227A family with sequence similarity 227 member A [ Homo sapiens (human) ]

    Gene ID: 646851, updated on 10-Oct-2024

    Summary

    Official Symbol
    FAM227Aprovided by HGNC
    Official Full Name
    family with sequence similarity 227 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:44197
    See related
    Ensembl:ENSG00000184949 AllianceGenome:HGNC:44197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 1.8), thyroid (RPKM 0.5) and 11 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FAM227A in Genome Data Viewer
    Location:
    22q13.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (38578118..38656392, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (39042376..39126576, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38974123..39052397, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373031 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:38966777-38967287 Neighboring gene ribosomal protein S29 pseudogene 31 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19014 Neighboring gene MPRA-validated peak4492 silencer Neighboring gene MPRA-validated peak4493 silencer Neighboring gene chibby 1, beta catenin antagonist Neighboring gene TOMM22 divergent transcript Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr22:39077750-39078949

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein FAM227A
    Names
    Protein FAM227A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013647.2NP_001013669.1  protein FAM227A isoform 1

      See identical proteins and their annotated locations for NP_001013669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK301819, AL022320, DA378202, DB053353, DV080205
      Consensus CDS
      CCDS93164.1
      UniProtKB/Swiss-Prot
      B0QY52, B7Z7C6, F5H4B4, Q5TG08
      UniProtKB/TrEMBL
      A0A2R8YCE3
      Related
      ENSP00000445093.1, ENST00000535113.7
      Conserved Domains (1) summary
      pfam14922
      Location:146296
      FWWh; Protein of unknown function
    2. NM_001291030.2NP_001277959.1  protein FAM227A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK301819, AL022320, DA378202, DV080205
      UniProtKB/Swiss-Prot
      F5H4B4
      Conserved Domains (1) summary
      pfam14922
      Location:42203
      FWWh; Protein of unknown function
    3. NM_001384270.1NP_001371199.1  protein FAM227A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL021707, AL022320, AL035495
      UniProtKB/TrEMBL
      A0A2R8YCE3
      Conserved Domains (1) summary
      pfam14922
      Location:53203
      FWWh; Protein of unknown function
    4. NM_001384271.1NP_001371200.1  protein FAM227A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL021707, AL022320, AL035495
      Conserved Domains (1) summary
      pfam14922
      Location:1104
      FWWh; Protein of unknown function

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      38578118..38656392 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441459.1XP_047297415.1  protein FAM227A isoform X9

    2. XM_011530311.2XP_011528613.1  protein FAM227A isoform X6

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:94255
      FWWh; Protein of unknown function
    3. XM_047441456.1XP_047297412.1  protein FAM227A isoform X5

    4. XM_011530310.2XP_011528612.1  protein FAM227A isoform X4

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:135261
      FWWh; Protein of unknown function
    5. XM_006724292.3XP_006724355.2  protein FAM227A isoform X2

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:135296
      FWWh; Protein of unknown function
    6. XM_011530309.3XP_011528611.1  protein FAM227A isoform X3

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Related
      ENSP00000348086.7, ENST00000355830.11
      Conserved Domains (1) summary
      pfam14922
      Location:135296
      FWWh; Protein of unknown function
    7. XM_006724291.3XP_006724354.2  protein FAM227A isoform X1

      See identical proteins and their annotated locations for XP_006724354.2

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:135296
      FWWh; Protein of unknown function
    8. XM_011530308.4XP_011528610.1  protein FAM227A isoform X1

      See identical proteins and their annotated locations for XP_011528610.1

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:135296
      FWWh; Protein of unknown function
    9. XM_011530313.3XP_011528615.1  protein FAM227A isoform X7

      See identical proteins and their annotated locations for XP_011528615.1

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:42203
      FWWh; Protein of unknown function
    10. XM_011530312.3XP_011528614.1  protein FAM227A isoform X7

      See identical proteins and their annotated locations for XP_011528614.1

      UniProtKB/TrEMBL
      A0A0A0MRD0
      Conserved Domains (1) summary
      pfam14922
      Location:42203
      FWWh; Protein of unknown function
    11. XM_047441458.1XP_047297414.1  protein FAM227A isoform X8

    12. XM_047441457.1XP_047297413.1  protein FAM227A isoform X7

    RNA

    1. XR_937892.2 RNA Sequence

      Related
      ENST00000544346.5
    2. XR_937893.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      39042376..39126576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325831.1XP_054181806.1  protein FAM227A isoform X9

    2. XM_054325826.1XP_054181801.1  protein FAM227A isoform X6

    3. XM_054325825.1XP_054181800.1  protein FAM227A isoform X5

    4. XM_054325824.1XP_054181799.1  protein FAM227A isoform X4

    5. XM_054325822.1XP_054181797.1  protein FAM227A isoform X2

    6. XM_054325823.1XP_054181798.1  protein FAM227A isoform X3

    7. XM_054325820.1XP_054181795.1  protein FAM227A isoform X1

    8. XM_054325821.1XP_054181796.1  protein FAM227A isoform X1

    9. XM_054325829.1XP_054181804.1  protein FAM227A isoform X7

    10. XM_054325827.1XP_054181802.1  protein FAM227A isoform X7

    11. XM_054325830.1XP_054181805.1  protein FAM227A isoform X8

    12. XM_054325828.1XP_054181803.1  protein FAM227A isoform X7

    RNA

    1. XR_008485408.1 RNA Sequence

    2. XR_008485409.1 RNA Sequence