U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Arhgef19 Rho guanine nucleotide exchange factor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362648, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Arhgef19provided by RGD
    Official Full Name
    Rho guanine nucleotide exchange factor 19provided by RGD
    Primary source
    RGD:1304766
    See related
    EnsemblRapid:ENSRNOG00000047967 AllianceGenome:RGD:1304766
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of actin cytoskeleton organization and wound healing. Predicted to act upstream of or within positive regulation of GTPase activity. Orthologous to human ARHGEF19 (Rho guanine nucleotide exchange factor 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 41.1), Kidney (RPKM 11.9) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Arhgef19 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158818840..158837196)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153536038..153554203)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159754954..159773699)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487028 Neighboring gene F-box protein 42 Neighboring gene ciliogenesis and planar polarity effector 2-like Neighboring gene uncharacterized LOC108351054 Neighboring gene ciliogenesis and planar polarity effector complex subunit 2 Neighboring gene Eph receptor A2 Neighboring gene ribosomal protein S27a, pseudogene 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Caddy J, et al. Dev Cell, 2010 Jul 20. PMID 20643356, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rho guanine nucleotide exchange factor 19
    Names
    Rho guanine nucleotide exchange factor (GEF) 19

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108692.1 → NP_001102162.1  rho guanine nucleotide exchange factor 19

      See identical proteins and their annotated locations for NP_001102162.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A6ITS3, D4A646
      Related
      ENSRNOP00000061876.3, ENSRNOT00000067574.5
      Conserved Domains (4) summary
      cd01221
      Location:666 → 792
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:679 → 786
      PH; PH domain
      pfam00621
      Location:468 → 645
      RhoGEF; RhoGEF domain
      cl17036
      Location:805 → 859
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      158818840..158837196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764270.4 → XP_008762492.1  rho guanine nucleotide exchange factor 19 isoform X1

      See identical proteins and their annotated locations for XP_008762492.1

      UniProtKB/TrEMBL
      A0A8I6ALI5, A6ITS4
      Related
      ENSRNOP00000093983.1, ENSRNOT00000096539.2
      Conserved Domains (4) summary
      cd01221
      Location:617 → 743
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00169
      Location:630 → 737
      PH; PH domain
      pfam00621
      Location:419 → 596
      RhoGEF; RhoGEF domain
      cl17036
      Location:756 → 810
      SH3; Src Homology 3 domain superfamily

    2. XM_008764272.4 → XP_008762494.1  rho guanine nucleotide exchange factor 19 isoform X2

      See identical proteins and their annotated locations for XP_008762494.1

      UniProtKB/TrEMBL
      A6ITS5
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily

    3. XM_039110425.2 → XP_038966353.1  rho guanine nucleotide exchange factor 19 isoform X2

      UniProtKB/TrEMBL
      A6ITS5
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily

    4. XM_017593525.3 → XP_017449014.1  rho guanine nucleotide exchange factor 19 isoform X2

      UniProtKB/TrEMBL
      A6ITS5
      Related
      ENSRNOP00000104066.1, ENSRNOT00000153266.1
      Conserved Domains (3) summary
      cd01221
      Location:584 → 710
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain
      pfam00621
      Location:386 → 562
      RhoGEF; RhoGEF domain
      cl17036
      Location:723 → 777
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous