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    Drak Death-associated protein kinase related [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32097, updated on 4-Jul-2024

    Summary

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    Official Symbol
    Drakprovided by FlyBase
    Official Full Name
    Death-associated protein kinase relatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0052666
    Locus tag
    Dmel_CG32666
    See related
    AllianceGenome:FB:FBgn0052666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11713; CG1760; CG32666; Dmel\CG32666; drak; DRak; EP(X)1452; EP1452
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in imaginal disc-derived leg morphogenesis; imaginal disc-derived wing morphogenesis; and protein phosphorylation. Predicted to be active in nucleus. Is expressed in haltere disc; organism; ventral thoracic disc; and wing disc. Orthologous to human STK17A (serine/threonine kinase 17a) and STK17B (serine/threonine kinase 17b). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Drak in Genome Data Viewer
    Location:
    10C1-10C5; 1-35 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11493135..11555045)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11387168..11449078)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44556 Neighboring gene Spase 25-subunit Neighboring gene uncharacterized protein Neighboring gene mir-2492 stem loop Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein SA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue. Aranjuez G, et al. Mol Biol Cell, 2016 Jun 15. PMID 27122602, Free PMC Article
    2. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis. Robertson F, et al. Development, 2012 Sep. PMID 22874916, Free PMC Article
    3. Drak Is Required for Actomyosin Organization During Drosophila Cellularization. Chougule AB, et al. G3 (Bethesda), 2016 Apr 7. PMID 26818071, Free PMC Article
    4. Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. Champagne MB, et al. J Mol Biol, 2000 Jul 21. PMID 10891286
    5. Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis. Neubueser D, et al. Mol Biol Cell, 2010 Aug 15. PMID 20573980, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
      Title: Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
    2. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
      Title: Overlapping roles of Drosophila Drak and Rok kinases in epithelial tissue morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in morphogenesis of an epithelium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Death-associated protein kinase related
    Names
    CG32666-PC
    CG32666-PD
    CG32666-PE
    Drak-PC
    Drak-PD
    Drak-PE
    NP_001162723.1
    NP_001162724.1
    NP_996411.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11493135..11555045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169253.2 → NP_001162724.1  Death-associated protein kinase related, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJH9, Q0KHT7, Q86P19
      Conserved Domains (3) summary
      PHA03255
      Location:379 → 554
      PHA03255; BDLF3; Provisional
      smart00220
      Location:45 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14106
      Location:28 → 295
      STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase

    2. NM_001169252.2 → NP_001162723.1  Death-associated protein kinase related, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJH9, Q0KHT7, Q86P19
      Conserved Domains (3) summary
      PHA03255
      Location:379 → 554
      PHA03255; BDLF3; Provisional
      smart00220
      Location:45 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14106
      Location:28 → 295
      STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase

    3. NM_206688.2 → NP_996411.2  Death-associated protein kinase related, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996411.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1JJH9, Q0KHT7, Q86P19
      Conserved Domains (3) summary
      PHA03255
      Location:379 → 554
      PHA03255; BDLF3; Provisional
      smart00220
      Location:45 → 295
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14106
      Location:28 → 295
      STKc_DRAK; Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0KHT7.2 Q0KHT7

    Gene LinkOut

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