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    Awh Arrowhead [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38451, updated on 10-May-2024

    Summary

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    Official Symbol
    Awhprovided by FlyBase
    Official Full Name
    Arrowheadprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013751
    Locus tag
    Dmel_CG1072
    See related
    AllianceGenome:FB:FBgn0013751
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    awh; CG1072; Dmel\CG1072; l(3)63Ea; l(3)63Ea/Awh; l(3)64Ea; l(3)SH9; l63Ea
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in compound eye development; imaginal disc development; and regulation of gene expression. Predicted to be active in nucleus. Is expressed in several structures, including anterior ectoderm anlage; ectoderm; embryonic segment; extended germ band embryo; and presumptive embryonic/larval system. Orthologous to human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Awh in Genome Data Viewer
    Location:
    63F4-63F4; 3-9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3846206..3861692)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3846206..3861692)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Succinyl-coenzyme A synthetase alpha subunit 1 Neighboring gene Accessory gland protein 63F Neighboring gene encore Neighboring gene Red herring Neighboring gene long non-coding RNA:CR45379 Neighboring gene long non-coding RNA:CR43917

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Establishment of Drosophila imaginal precursor cells is controlled by the Arrowhead gene. Curtiss J, et al. Development, 1995 Nov. PMID 8582291
    2. Evolved Repression Overcomes Enhancer Robustness. Preger-Ben Noon E, et al. Dev Cell, 2016 Dec 5. PMID 27840106
    3. DeLIMiting development. Curtiss J, et al. Bioessays, 1998 Jan. PMID 9504048
    4. Arrowhead encodes a LIM homeodomain protein that distinguishes subsets of Drosophila imaginal cells. Curtiss J, et al. Dev Biol, 1997 Oct 1. PMID 9331336
    5. LIM domains: multiple roles as adapters and functional modifiers in protein interactions. Dawid IB, et al. Trends Genet, 1998 Apr. PMID 9594664

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in compound eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    arrowhead
    Names
    Awh-PA
    Awh-PB
    Awh-PC
    Awh-PD
    CG1072-PA
    CG1072-PB
    CG1072-PC
    CG1072-PD
    lethal(3)63Ea

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3846206..3861692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168042.2 → NP_728906.1  arrowhead, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18547, Q1LYZ6, Q8IRC7, Q8SZ10, Q9VZM0
      Related
      FBpp0073014
      Conserved Domains (3) summary
      cd09373
      Location:8 → 61
      LIM1_AWH; The first LIM domain of Arrowhead (AWH)
      cd09379
      Location:69 → 123
      LIM2_AWH; The second LIM domain of Arrowhead (AWH)
      pfam00046
      Location:152 → 205
      Homeobox; Homeobox domain

    2. NM_001274450.1 → NP_001261379.1  arrowhead, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261379.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEI5
      Conserved Domains (3) summary
      cd09373
      Location:8 → 61
      LIM1_AWH; The first LIM domain of Arrowhead (AWH)
      cd09379
      Location:69 → 123
      LIM2_AWH; The second LIM domain of Arrowhead (AWH)
      pfam00046
      Location:152 → 204
      Homeobox; Homeobox domain

    3. NM_079183.3 → NP_523907.2  arrowhead, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523907.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IRC7
      Related
      FBpp0073013
      Conserved Domains (3) summary
      cd09373
      Location:8 → 61
      LIM1_AWH; The first LIM domain of Arrowhead (AWH)
      pfam00046
      Location:152 → 205
      Homeobox; Homeobox domain
      cl02475
      Location:69 → 123
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. NM_001274451.1 → NP_001261380.1  arrowhead, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261380.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE75
      Conserved Domains (3) summary
      cd09373
      Location:8 → 61
      LIM1_AWH; The first LIM domain of Arrowhead (AWH)
      cd09379
      Location:69 → 123
      LIM2_AWH; The second LIM domain of Arrowhead (AWH)
      pfam00046
      Location:152 → 205
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PE75 M9PE75
    M9PEI5 M9PEI5
    Q8IRC7.1 Q8IRC7

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