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    Nudt16l1 nudix hydrolase 16 like 1 [ Mus musculus (house mouse) ]

    Gene ID: 66911, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nudt16l1provided by MGI
    Official Full Name
    nudix hydrolase 16 like 1provided by MGI
    Primary source
    MGI:MGI:1914161
    See related
    Ensembl:ENSMUSG00000022516 AllianceGenome:MGI:1914161
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sdos; syndesmos; 1110001K21Rik; 5330437I08Rik
    Summary
    Predicted to enable snoRNA binding activity. Predicted to be involved in negative regulation of double-strand break repair via nonhomologous end joining. Predicted to be active in nucleus. Orthologous to human NUDT16L1 (nudix hydrolase 16 like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in kidney adult (RPKM 49.1), adrenal adult (RPKM 46.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nudt16l1 in Genome Data Viewer
    Location:
    16 A1; 16 2.48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4756975..4758892)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4939111..4941028)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4878205-4878392 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4879753-4879936 Neighboring gene STARR-positive B cell enhancer ABC_E1919 Neighboring gene UBA-like domain containing 1 Neighboring gene mahogunin, ring finger 1 Neighboring gene STARR-positive B cell enhancer mm9_chr16:4938936-4939237 Neighboring gene predicted gene, 16861 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene predicted gene, 36681 Neighboring gene dynein axonemal assembly factor 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity. Tsaousidou E, et al. Cell Rep, 2024 Jun 25. PMID 38861384, Free PMC Article
    2. Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5. Denhez F, et al. J Biol Chem, 2002 Apr 5. PMID 11805099
    3. Multiple mRNA decapping enzymes in mammalian cells. Song MG, et al. Mol Cell, 2010 Nov 12. PMID 21070968, Free PMC Article
    4. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables phosphodiesterase decapping endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables snoRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of double-strand break repair via nonhomologous end joining ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in sno(s)RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tudor-interacting repair regulator protein
    Names
    NUDT16-like protein 1
    nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1
    protein syndesmos

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316715.1 → NP_001303644.1  tudor-interacting repair regulator protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK003241, BQ030979, CF160100
      Consensus CDS
      CCDS88870.1
      UniProtKB/Swiss-Prot
      Q8VHN8
      Related
      ENSMUSP00000054201.10, ENSMUST00000050881.10

    2. NM_025839.4 → NP_080115.1  tudor-interacting repair regulator protein isoform 1

      See identical proteins and their annotated locations for NP_080115.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK003241, BQ030979
      Consensus CDS
      CCDS27927.1
      UniProtKB/Swiss-Prot
      Q3TW47, Q8R039, Q8R3D9, Q8VHN8, Q9CR90, Q9D8M0
      UniProtKB/TrEMBL
      A0A2R8VH99
      Related
      ENSMUSP00000155142.2, ENSMUST00000230931.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      4756975..4758892
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHN8.2 GenPept UniProtKB/Swiss-Prot:Q8VHN8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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