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    Rab26 RAB26, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171111, updated on 10-Jul-2024

    Summary

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    Symbol
    Rab26provided by RGD
    Full Name
    RAB26, member RAS oncogene familyprovided by RGD
    Primary source
    RGD:620890
    See related
    EnsemblRapid:ENSRNOG00000042086 AllianceGenome:RGD:620890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GTP binding activity. Involved in exocrine system development and regulation of exocytosis. Is intrinsic component of plasma membrane. Orthologous to human RAB26 (RAB26, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 109.0), Spleen (RPKM 25.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rab26 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14057942..14062602, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13553395..13558063, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13894271..13898578, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 7 Neighboring gene uncharacterized LOC102551976 Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene transfer RNA serine (anticodon AGA) 42 Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene TSC complex subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of a new member of the Rab protein family, Rab 26, from rat pancreas. Wagner AC, et al. Biochem Biophys Res Commun, 1995 Feb 27. PMID 7864900
    2. Expression, characterization, and localization of Rab26, a low molecular weight GTP-binding protein, in the rat parotid gland. Yoshie S, et al. Histochem Cell Biol, 2000 Apr. PMID 10857477
    3. The GTPase Rab26 links synaptic vesicles to the autophagy pathway. Binotti B, et al. Elife, 2015 Feb 2. PMID 25643395, Free PMC Article
    4. Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi. Li C, et al. J Biol Chem, 2012 Dec 14. PMID 23105096, Free PMC Article
    5. Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Lüningschrör P, et al. Nat Commun, 2017 Oct 30. PMID 29084947, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures.
      Title: The GTPase Rab26 links synaptic vesicles to the autophagy pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GMP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GTP binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Golgi to plasma membrane protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in exocrine system development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in exocrine system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocrine system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulated exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulated exocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation protein catabolic process at presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation protein catabolic process at presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secretory granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ras-related protein Rab-26

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133580.2 → NP_598264.2  ras-related protein Rab-26

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      P51156, Q6P6W7
      UniProtKB/TrEMBL
      A6HCT9
      Conserved Domains (1) summary
      cd04112
      Location:65 → 255
      Rab26; Rab GTPase family 26 (Rab26)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14057942..14062602 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085125.2 → XP_038941053.1  ras-related protein Rab-26 isoform X2

      Conserved Domains (1) summary
      cl38936
      Location:65 → 302
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_039085122.2 → XP_038941050.1  ras-related protein Rab-26 isoform X1

      Conserved Domains (1) summary
      cl38936
      Location:65 → 326
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_039085140.2 → XP_038941068.1  ras-related protein Rab-26 isoform X10

      Conserved Domains (1) summary
      cl38936
      Location:65 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    4. XM_039085128.2 → XP_038941056.1  ras-related protein Rab-26 isoform X3

      Conserved Domains (1) summary
      cl38936
      Location:65 → 293
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_039085136.2 → XP_038941064.1  ras-related protein Rab-26 isoform X7

      Conserved Domains (1) summary
      cl38936
      Location:65 → 242
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_039085134.2 → XP_038941062.1  ras-related protein Rab-26 isoform X5

      Conserved Domains (1) summary
      cl38936
      Location:65 → 266
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. XM_039085146.2 → XP_038941074.1  ras-related protein Rab-26 isoform X14

      Conserved Domains (1) summary
      cl38936
      Location:65 → 168
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    8. XM_039085138.2 → XP_038941066.1  ras-related protein Rab-26 isoform X9

      Conserved Domains (1) summary
      cl38936
      Location:65 → 223
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    9. XM_039085137.2 → XP_038941065.1  ras-related protein Rab-26 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZZI4
      Related
      ENSRNOP00000083203.1, ENSRNOT00000097378.2
      Conserved Domains (1) summary
      cd04112
      Location:65 → 233
      Rab26; Rab GTPase family 26 (Rab26)

    10. XM_063268366.1 → XP_063124436.1  ras-related protein Rab-26 isoform X6

      UniProtKB/TrEMBL
      A0A8L2Q1F9
      Related
      ENSRNOP00000004249.5, ENSRNOT00000004249.8

    11. XM_039085130.2 → XP_038941058.1  ras-related protein Rab-26 isoform X4

      Related
      ENSRNOP00000104150.1, ENSRNOT00000144497.1
      Conserved Domains (1) summary
      cd04112
      Location:65 → 288
      Rab26; Rab GTPase family 26 (Rab26)

    12. XM_039085147.2 → XP_038941075.1  ras-related protein Rab-26 isoform X15

      Conserved Domains (1) summary
      cl38936
      Location:65 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    13. XM_039085144.2 → XP_038941072.1  ras-related protein Rab-26 isoform X12

      Conserved Domains (1) summary
      cl38936
      Location:65 → 157
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    14. XM_039085143.2 → XP_038941071.1  ras-related protein Rab-26 isoform X11

      Conserved Domains (1) summary
      cl38936
      Location:65 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    15. XM_039085145.2 → XP_038941073.1  ras-related protein Rab-26 isoform X13

      Conserved Domains (1) summary
      cl38936
      Location:65 → 139
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    16. XM_063268368.1 → XP_063124438.1  ras-related protein Rab-26 isoform X16

    RNA

    1. XR_010055125.1 RNA Sequence

    2. XR_005489682.2 RNA Sequence

    3. XR_005489684.2 RNA Sequence

    4. XR_005489683.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51156.2 GenPept UniProtKB/Swiss-Prot:P51156

    Gene LinkOut

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